Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000, Israel.
J Am Chem Soc. 2023 Jun 14;145(23):12429-12445. doi: 10.1021/jacs.3c00282. Epub 2023 May 31.
The renaissance in corrole chemistry is strongly correlated with synthetic breakthroughs that started in 1999, regarding the one-pot rather than multistep syntheses of this heme-like N4 macrocycle. This largely improved synthetic accessibility allowed for technological advances wherein the corresponding metal complexes have since been introduced as key elements. Great emphasis was devoted to the elucidation of the unique fundamental features that distinguish corrole ligands, among them outstanding electron donation (σ by the N atoms and π by the macrocycle) to transition metals chelated by them. Such investigations remain crucial for enabling the by-demand tuning of metallocorrole properties for distinctly different applications. These range from the catalysis of organic reactions, through bioimaging and disease prevention/treatment strategies, to photo- and electrocatalysis for clean energy. Surveyed are the original reports that impacted these developments, together with some of the most recent advances.
卟啉化学的复兴与 1999 年开始的合成突破密切相关，涉及卟啉类似物 N4 大环的一锅法而不是多步合成。这种在很大程度上提高的合成可及性使得相应的金属配合物作为关键元素被引入技术进步中。人们非常重视阐明区分卟啉配体的独特基本特征，其中包括它们向被其螯合的过渡金属提供出色的电子供体（N 原子的 σ 和大环的 π）。这些研究对于实现对金属卟啉性质的按需调节以适应截然不同的应用仍然至关重要。这些应用从有机反应的催化，通过生物成像和疾病预防/治疗策略，到用于清洁能源的光催化和电催化。综述了这些发展的原始报告，以及一些最新进展。
