Department of Chemistry, Visva-Bharati, Santiniketan, West Bengal 731235, India.
Org Lett. 2023 Jun 9;25(22):4183-4187. doi: 10.1021/acs.orglett.3c01498. Epub 2023 May 31.
An iminoiodane-enabled oxidative ring-opening of 2-indazoles via C-N bond cleavage has been developed under metal-free reaction conditions. This methodology afforded a new array of unsymmetrical --acylsulfonamidated azobenzenes with a wide functional group tolerance in good yields. The reaction potentially proceeds through the formation of a zwitterionic adduct, which is formed by the reaction between 2-indazoles and iminoiodane.
在无金属反应条件下，开发了一种通过 C-N 键断裂实现 2-吲哚氧化开环的亚胺碘烷方法。该方法以良好的收率提供了一系列具有广泛官能团容忍度的新型不对称 --酰基磺酰胺化偶氮苯。该反应可能通过形成两性离子加合物来进行，该加合物是通过 2-吲哚与亚胺碘烷之间的反应形成的。
