Murtaza Ayesha, Ulhaq Zia, Shirinfar Bahareh, Rani Sadia, Aslam Samina, Martins Guilherme M, Ahmed Nisar
Department of Chemistry, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, 64200, Pakistan.
Chemical Engineering Department, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, 64200, Pakistan.
Chem Rec. 2023 Oct;23(10):e202300119. doi: 10.1002/tcr.202300119. Epub 2023 May 31.
C-H bond functionalization generates molecular complexity in single-step transformation. However, the activation of C-H bonds requires expensive metals or stoichiometric amounts of oxidizing/reducing species. In many cases, they often require pre-functionalization of starting molecules. Such pre-activating measures cause waste generation and their separation from the final product is also troublesome. In such a scenario, reactions activating elements generating from renewable energy resources such as electricity and light would be more efficient, green, and cost-effective. Further, incorporation of growing flow technology in chemical transformation processes will accelerate the safer accesses of valuable products. Arenes & heteroarenes are ubiquitous in pharmaceuticals, natural products, medicinal compounds, and other biologically important molecules. Herein, we discussed enabling tools and technologies used for the recent C-H bonds functionalization of arenes and heteroarenes.
碳氢键官能团化在单步转化中产生分子复杂性。然而，碳氢键的活化需要昂贵的金属或化学计量的氧化/还原物种。在许多情况下，它们通常需要起始分子的预官能团化。这种预活化措施会产生废物，并且将它们与最终产物分离也很麻烦。在这种情况下，利用可再生能源（如电和光）产生的元素进行活化的反应将更高效、绿色且具有成本效益。此外，在化学转化过程中引入不断发展的流动技术将加速更安全地获得有价值的产品。芳烃和杂芳烃广泛存在于药物、天然产物、药用化合物和其他具有生物学重要性的分子中。在此，我们讨论了用于近期芳烃和杂芳烃碳氢键官能团化的使能工具和技术。
