Zufry Hendra, Rudijanto Achmad, Soeatmadji Djoko Wahono, Sakti Setyawan Purnomo, Munadi Khairul, Sujuti Hidayat, Mintaroem Karyono
Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia.
Division of Endocrinology, Metabolism, and Diabetes, Thyroid Center, Department of Internal Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin General Teaching Hospital, Banda Aceh, Aceh, Indonesia.
J Adv Pharm Technol Res. 2023 Apr-Jun;14(2):63-68. doi: 10.4103/japtr.japtr_680_22. Epub 2023 Apr 13.
The aim of this study was to investigate the effects of mobile phone electromagnetic radiation (MP-EMR) on the thyroid glands and hormones in brain in term of thyroid function, reactive oxygen species (ROS), and monocarboxylate transporter 8 (MCT8) concentration. Forty rats were divided into different groups: control (without EMR exposure), EMR1 (120-min/day exposure), EMR2 (150-min), and EMR3 (180-min). The levels of serum thyroid stimulating hormone (TSH), thyroxine (T), and malondialdehyde (MDA) and brain and MCT8 were measured using enzyme-linked immunosorbent assay. One-way analysis of variance followed by the Duncan test was used to analyze the data. Our data indicated that the levels of serum TSH and T in all the EMR groups were lower significant postexposure compared to the control with < 0.01 (EMR1 and EMR2) and < 0.001 (EMR3), suggesting hypothyroidism due to MP-EMR exposure. Increased MDA and decreased MCT8 levels were also observed following the intervention; however, the changes in both concentrations were notably significant after being subjected to 150-min and 180-min of exposure. In conclusion, a significant reduction in TSH, T, and MCT8 levels indicated thyroid dysfunction due to MP-EMR exposure.
本研究旨在从甲状腺功能、活性氧（ROS）和单羧酸转运体8（MCT8）浓度方面，探讨手机电磁辐射（MP - EMR）对大鼠甲状腺及大脑中激素的影响。将40只大鼠分为不同组：对照组（无电磁辐射暴露）、EMR1组（每天暴露120分钟）、EMR2组（每天暴露150分钟）和EMR3组（每天暴露180分钟）。采用酶联免疫吸附测定法检测血清促甲状腺激素（TSH）、甲状腺素（T）、丙二醛（MDA）水平以及大脑中的MCT8水平。数据采用单因素方差分析，随后进行邓肯检验。我们的数据表明，与对照组相比，所有电磁辐射组暴露后血清TSH和T水平显著降低，EMR1组和EMR2组P < 0.01，EMR3组P < 0.001，提示MP - EMR暴露导致甲状腺功能减退。干预后还观察到MDA水平升高和MCT8水平降低；然而，在暴露150分钟和180分钟后，这两种浓度的变化均显著。总之，TSH、T和MCT8水平显著降低表明MP - EMR暴露导致甲状腺功能障碍。
