Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian, 116044, China.
Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Chem Biol Interact. 2023 Aug 25;381:110575. doi: 10.1016/j.cbi.2023.110575. Epub 2023 May 29.
Di-ethylhexyl phthalate (DEHP) is used as an important plasticizer in a wide range of products such as paints, food packaging, medical devices and children's toys. In recent years, there has been increasing interest in the toxic effects of DEHP on the male reproductive organs, the testicles. Here, we reviewed the basic pathways of testicular damage caused by DEHP. The mechanism involves oxidative stress, ferroptosis, interfering with hypothalamic-pituitary-gonadal axis (HPGA) and testosterone level. We summarized the protective agents that have been shown to be effective in repairing this type of testicular damage in recent years. This provides a new perspective and direction for future research into the health effects and molecular mechanisms of DEHP.
邻苯二甲酸二（2-乙基）己酯（DEHP）作为一种重要的增塑剂，广泛应用于涂料、食品包装、医疗器械和儿童玩具等产品中。近年来，人们对 DEHP 对睾丸等男性生殖器官的毒性作用越来越关注。在这里，我们综述了 DEHP 引起睾丸损伤的基本途径。其机制涉及氧化应激、铁死亡、干扰下丘脑-垂体-性腺轴（HPGA）和睾酮水平。我们总结了近年来已被证明对修复这种类型的睾丸损伤有效的保护剂。这为研究 DEHP 的健康影响和分子机制提供了新的视角和方向。
