Department of Nuclear Medicine, INF 400, University Hospital Heidelberg, Heidelberg, Germany; Deaprtment of Nuclear medicine, Geb. 13.55, Moorenstraße 5, 40225 Düsseldorf.
Department of Radiooncology and Radiation Therapy, Krankenhaus Barmherzige Brüder, Prüfeninger Str. 86 93049 Regensburg, Germany; Department of Radiooncology and Radiation Therapy, University Hospital Heidelberg.
PET Clin. 2023 Jul;18(3):345-351. doi: 10.1016/j.cpet.2023.03.005.
68Ga-FAPI-PET/computed tomography (CT) is a novel PET/CT radiotracer particularly developed for oncologic imaging. Gynecologic malignancies comprise a broad spectrum of entities and, along with breast cancer, constitute cancers occurring exclusively or primarily, respectively, in women. Thus, a tracer designed not only for one but multiple malignancies has theoretic attractions. Even in comparison with 18F-FDG, the current standard oncologic tracer of nuclear medicine, 68Ga-FAPI, has demonstrated advantages in several tumors. As breast cancer, ovarian cancer, and cervical cancer are among the most common tumor types in women and are often accompanied by high morbidity as well as mortality rates, a reliable staging tool is paramount for optimal therapeutic management.
68Ga-FAPI-PET/计算机断层扫描（CT）是一种新型的 PET/CT 放射性示踪剂，专门用于肿瘤成像。妇科恶性肿瘤包括广泛的实体瘤，与乳腺癌一起，分别是女性特有的或主要发生的癌症。因此，设计一种不仅针对一种而是多种恶性肿瘤的示踪剂具有理论吸引力。即使与 18F-FDG（核医学目前的标准肿瘤示踪剂）相比，68Ga-FAPI 在几种肿瘤中也表现出了优势。由于乳腺癌、卵巢癌和宫颈癌是女性最常见的肿瘤类型之一，并且往往伴随着高发病率和死亡率，因此，对于最佳治疗管理，可靠的分期工具至关重要。
