病理学家在肾细胞癌管理中的作用。

The Role of the Pathologist in Renal Cell Carcinoma Management.

机构信息

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Merkin Building, 415 Main Street, Cambridge, MA 02142, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

出版信息

Hematol Oncol Clin North Am. 2023 Oct;37(5):849-862. doi: 10.1016/j.hoc.2023.04.014. Epub 2023 May 29.

DOI:10.1016/j.hoc.2023.04.014

PMID:37258353

Abstract

Recent advances in our understanding of the molecular alterations underlying different types of renal cell carcinoma (RCC), as well as the implementation of immune checkpoint inhibitors in the treatment of patients with advanced disease, have significantly expanded the role of pathologists in the management of RCC patients and in the identification of predictive biomarkers that can guide patient treatment. In this chapter, we examine pathologists' evolving role in patient care and the development of precision medicine strategies for RCC.

摘要

近年来，我们对不同类型肾细胞癌（RCC）的分子改变有了更深入的了解，免疫检查点抑制剂在晚期疾病患者的治疗中的应用也得到了广泛推广，这使得病理学家在 RCC 患者的管理以及识别能够指导患者治疗的预测性生物标志物方面的作用得到了显著扩展。在本章中，我们将探讨病理学家在患者护理中的不断发展的作用以及针对 RCC 的精准医疗策略的发展。