Elmer G I, Meisch R A, George F R
Pharmacol Biochem Behav. 1986 May;24(5):1417-21. doi: 10.1016/0091-3057(86)90204-2.
The use of genetically defined animals in many areas of alcohol research provides valuable information about the contribution of genetic factors to ethanol-related behaviors. Utilizing the principles of operant conditioning, we determined whether mice which are known for high ethanol preference, C57BL/6J males, would orally self-administer this substance. Strategies used with other species were successful in inducing pharmacologically significant blood alcohol levels and in establishing ethanol as a reinforcer in this mouse strain. Responding for and consumption of 8% (w/v) ethanol exceeded baseline levels of responding for water. This species and method may prove useful in determining the genetic relationship among various ethanol-related behaviors and their mechanisms of action and in studies of behavior reinforced by drugs.
在酒精研究的许多领域中，使用基因定义的动物能够提供有关遗传因素对乙醇相关行为影响的有价值信息。利用操作性条件反射原理，我们确定了以高乙醇偏好闻名的小鼠（C57BL/6J雄性小鼠）是否会经口自我给药这种物质。用于其他物种的策略成功诱导出了具有药理学意义的血液酒精水平，并确立了乙醇作为该小鼠品系中的一种强化物。对8%（w/v）乙醇的反应和消耗量超过了对水反应的基线水平。这种物种和方法可能有助于确定各种乙醇相关行为之间的遗传关系及其作用机制，以及用于药物强化行为的研究。
