Elmer G I, Meisch R A, George F R
Alcohol. 1987 Jan-Feb;4(1):63-8. doi: 10.1016/0741-8329(87)90062-0.
In an earlier study ethanol drinking was induced by reducing mice to 80% of their free-feeding weight and feeding them their daily food allotment prior to the experimental session. The mice were given an ascending series of ethanol concentrations (1 to 8%). The inducing condition was subsequently eliminated to determine if the drinking of 8% ethanol would persist in its absence. Eight percent ethanol served as a reinforcer for the C57BL/6J mice but not for the BALB/cJ mice. The purpose of the present study was to examine strain differences in ethanol maintained behavior over a range of concentrations from 1 to 32% (w/v). Ethanol served as a reinforcer for the C57BL/6J mice at concentrations of 4, 8 and 16%. Lever presses and volume of liquid consumed per unit of body weight were inverted U-shaped functions of ethanol concentration. Post-session blood ethanol levels confirmed intake of pharmacologically significant amounts of ethanol. Results with the BALB/cJ mice were very different from those with the C57BL/6J mice. The level of responding did not increase above baseline levels at any of the concentrations tested, and levels of responding decreased below baseline at 32%. Thus, ethanol did not serve as a reinforcer for the BALB/cJ mice at any of the concentrations tested. These results demonstrate that over a range of ethanol concentrations genotype is an important determinant of ethanol reinforced behavior.
在一项早期研究中，通过将小鼠体重减至自由进食体重的80%，并在实验时段前给予它们每日的食物配给量来诱导乙醇饮用。给小鼠提供一系列浓度递增的乙醇（1%至8%）。随后消除诱导条件，以确定在没有该条件的情况下，饮用8%乙醇的行为是否会持续。8%的乙醇对C57BL/6J小鼠起到强化物的作用，但对BALB/cJ小鼠则不然。本研究的目的是检验在1%至32%（w/v）的浓度范围内，乙醇维持行为的品系差异。在浓度为4%、8%和16%时，乙醇对C57BL/6J小鼠起到强化物的作用。杠杆按压次数和每单位体重消耗的液体量是乙醇浓度的倒U形函数。实验时段后的血液乙醇水平证实摄入了具有药理学意义的乙醇量。BALB/cJ小鼠的结果与C57BL/6J小鼠的结果非常不同。在任何测试浓度下，反应水平都没有高于基线水平，并且在32%时反应水平降至基线以下。因此，在任何测试浓度下，乙醇对BALB/cJ小鼠都没有起到强化物的作用。这些结果表明，在一系列乙醇浓度范围内，基因型是乙醇强化行为的一个重要决定因素。
