Habib F S, Attia M A, el-Shanawany S M
Pharmazie. 1986 Feb;41(2):124-5.
Effect of methylcellulose and polyethylene glycol (PEG1 and PEG2) gel formulations on in-vitro release of combination of 0.25% w/w physostigmine salicylate and 1% w/w pilocarpine hydrochloride was investigated in comparison with a fatty base containing the same drugs by using a stationary dialysis technique. The results showed that the release of both drugs was very slow from the fatty base while a maximum release was attained from methylcellulose gel formulation followed by PEG1 and then PEG2 gel formulations as indicated by the calculated area under curves (AUC) for the amounts of drugs released from different formulations.
采用静态透析技术，研究了甲基纤维素和聚乙二醇（PEG1和PEG2）凝胶制剂对0.25% w/w水杨酸毒扁豆碱与1% w/w盐酸毛果芸香碱组合体外释放的影响，并与含有相同药物的脂肪性基质进行了比较。结果表明，两种药物从脂肪性基质中的释放非常缓慢，而甲基纤维素凝胶制剂的释放量最大，其次是PEG1凝胶制剂，然后是PEG2凝胶制剂，这由不同制剂释放药物量的计算曲线下面积（AUC）表明。
