Ugri-Hunyadvari E, Biczók E, Kovács C
Pharmazie. 1986 Apr;41(4):247-9.
Using a hydrophilic and a lipophilic emulsifier the authors worked out a cream compound (having amphiphilic properties), which can be mixed with oil as well as with water. They convinced themselves that beyond the properties of the emulsifiers their ratio to each other is a crucial element in the development of the composition. They characterized changes in consistency when the composition was modified using rheological methods. In in vitro experiments they determined the influence of the base on the dissolution rate of the agent.
作者使用一种亲水性乳化剂和一种亲脂性乳化剂研制出一种具有两亲性的乳膏组合物，该组合物既能与油混合，也能与水混合。他们确信，除了乳化剂的性质外，它们彼此之间的比例是组合物开发中的关键因素。他们用流变学方法表征了组合物改性时稠度的变化。在体外实验中，他们测定了基质对药物溶解速率的影响。
