Götze M, Torner H, Kauffold P, König I, Dautzenberg H, Loth F
Pharmazie. 1986 Apr;41(4):250-3.
A new procedure of microencapsulation was studied with regard to substance release and quantification of diffusion processes on the capsule membrane. The permeability behaviour on the capsule membrane was especially studied in metabolites, which are essential for immobilized biological objects (i.g. preimplantative mammal embryos). Peptide and proteohormones, cyanmethemoglobin and proteins were enclosed in simple and multiple Symplex Capsules. All substances examined are able to pass the Symplex membrane. The speed of release is influenced by the size of the capsule, the ion force, temperature, concentration of immobilized substances as well as their linear and globular structur. Compared with simple capsules the release of substances from multiple capsules was delayed. Corresponding to the results found under the experimental design described the Symplex membrane can be considered as coating for the compartmentation of cells, that allows the passage of essential substances for the immobilized objects. The method of microencapsulation used and described has various ways of application.
研究了一种新的微囊化方法，涉及物质释放以及囊膜上扩散过程的量化。特别研究了囊膜对代谢物的渗透行为，这些代谢物对于固定化生物物体（如植入前的哺乳动物胚胎）至关重要。肽和蛋白激素、氰化高铁血红蛋白和蛋白质被包裹在单层和多层Simpl ex胶囊中。所有检测的物质都能够通过Simpl ex膜。释放速度受胶囊大小、离子强度、温度、固定化物质浓度及其线性和球状结构的影响。与单层胶囊相比，多层胶囊中物质的释放有所延迟。根据上述实验设计的结果，Simpl ex膜可被视为用于细胞分隔的包衣，它允许固定化物体的必需物质通过。所使用和描述的微囊化方法有多种应用方式。
