Torii-Goto Aya, Hirai Kana, Inukai Yuri, Hoshina Yoshimi, Shiomi Kazumi, Ito Junko, Yoshikawa Masae
Department of Pharmacy, College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-Ku, Nagoya, 463-8521, Japan.
Cure Pharma, 6-1-3 Shimoichiba-Cho, Toyota, 471-0875, Japan.
J Pharm Health Care Sci. 2023 Jun 1;9(1):19. doi: 10.1186/s40780-023-00288-9.
Insulin treatment is widely used not only for type 1 but also for type 2 diabetes patients. Insulin must be injected into the subcutaneous tissue to be effective. The needle length has been shortened for safety and efficiency. However, whether patients use an appropriate needle length is unclear.
Skin thickness was measured by ultrasound with patients in their usual posture during injection. Furthermore, the effect of the intervention in which the needle length was changed was investigated.
Thirty-eight percent of the patients had fluid leakage and injected the needle intradermally. The average skin thickness was 3.3 mm while sitting, which was greater than that in a previous report including measurements taken while lying down. Consequently, the skin thickness was > 4 mm in 9.5% of the patients who used 4-mm needles. Cases of leakage and intradermal injection decreased when the needle length was changed.
This study identified that the needle length should be considered in patients with thick skin or a lower body mass index due to possibility of intradermal injection.
胰岛素治疗不仅广泛应用于1型糖尿病患者，也用于2型糖尿病患者。胰岛素必须注射到皮下组织才能起效。为了安全和提高效率，针头长度已缩短。然而，患者是否使用了合适的针头长度尚不清楚。
在患者注射时以其通常姿势用超声测量皮肤厚度。此外，还研究了改变针头长度的干预措施的效果。
38%的患者出现液体渗漏并将针头注射到了真皮内。坐着时的平均皮肤厚度为3.3毫米，这比之前一份包括躺着时测量结果的报告中的数值要大。因此，在使用4毫米针头的患者中，9.5%的患者皮肤厚度超过4毫米。当改变针头长度时，渗漏和皮内注射的情况减少。
本研究发现，由于存在皮内注射的可能性，对于皮肤厚或体重指数较低的患者，应考虑针头长度。
