Institute of Endocrinology, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Endocr Res. 2023 Jul 3;48(2-3):68-76. doi: 10.1080/07435800.2023.2220022. Epub 2023 May 31.
Limited data are available regarding the association between pre-admission thyroid-stimulating hormone (TSH) levels and prognosis in hospitalized surgical patients treated for hypothyroidism. We retrospectively evaluated a cohort of 1,451 levothyroxine-treated patients, hospitalized to general surgery wards. The 30-day mortality risk was 2-fold higher for patients with TSH of 5.0-10.0 mIU/L (adjusted OR, 2.3; 95% CI 1.1-5.1), and 3-fold higher for those with TSH > 10.0 mIU/L (3.4; 95% CI 1.3-8.7). Long-term mortality risk was higher in patients with TSH of 5.0-10.0 and above 10.0 mIU/L (adjusted HR, 1.2; 95% CI, 1.0-1.6, and 1.7; 95% CI 1.2-2.4, respectively). We found that in levothyroxine-treated adults hospitalized to surgical wards, increased pre-admission TSH levels are associated with increased short- and long-term mortality.
关于住院接受甲状腺功能减退症治疗的外科患者入院前促甲状腺激素（TSH）水平与预后之间的关系，相关数据有限。我们回顾性评估了 1451 名接受左甲状腺素治疗的患者队列，这些患者住院于普通外科病房。TSH 为 5.0-10.0 mIU/L 的患者 30 天死亡率风险增加了 2 倍（调整后的 OR，2.3；95%CI，1.1-5.1），TSH>10.0 mIU/L 的患者 30 天死亡率风险增加了 3 倍（3.4；95%CI，1.3-8.7）。TSH 为 5.0-10.0 mIU/L 和 10.0 mIU/L 以上的患者长期死亡率风险更高（调整后的 HR，1.2；95%CI，1.0-1.6，和 1.7；95%CI，1.2-2.4）。我们发现，在住院于外科病房接受左甲状腺素治疗的成年患者中，入院前 TSH 水平升高与短期和长期死亡率增加相关。
