Guzmán-Mejía Fabiola, Godínez-Victoria Marycarmen, Molotla-Torres Daniel Efrain, Drago-Serrano Maria Elisa
Unidad Xochimilco, Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Ciudad de México CP 04960, Mexico.
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México CP 11340, Mexico.
Pharmaceuticals (Basel). 2023 Jan 31;16(2):214. doi: 10.3390/ph16020214.
Lactoferrin is an 80 kDa monomeric glycoprotein that exhibits multitask activities. Lactoferrin properties are of interest in the pharmaceutical field for the design of products with therapeutic potential, including nanoparticles and liposomes, among many others. In antimicrobial preparations, lactoferrin has been included either as a main bioactive component or as an enhancer of the activity and potency of first-line antibiotics. In some proposals based on nanoparticles, lactoferrin has been included in delivery systems to transport and protect drugs from enzymatic degradation in the intestine, favoring the bioavailability for the treatment of inflammatory bowel disease and colon cancer. Moreover, nanoparticles loaded with lactoferrin have been formulated as delivery systems to transport drugs for neurodegenerative diseases, which cannot cross the blood-brain barrier to enter the central nervous system. This manuscript is focused on pharmaceutical products either containing lactoferrin as the bioactive component or formulated with lactoferrin as the carrier considering its interaction with receptors expressed in tissues as targets of drugs delivered via parenteral or mucosal administration. We hope that this manuscript provides insights about the therapeutic possibilities of pharmaceutical Lf preparations with a sustainable approach that contributes to decreasing the resistance of antimicrobials and enhancing the bioavailability of first-line drugs for intestinal chronic inflammation and neurodegenerative diseases.
乳铁蛋白是一种80 kDa的单体糖蛋白，具有多种功能。乳铁蛋白的特性在制药领域备受关注，可用于设计具有治疗潜力的产品，包括纳米颗粒和脂质体等多种产品。在抗菌制剂中，乳铁蛋白既可以作为主要生物活性成分，也可以作为一线抗生素活性和效力的增强剂。在一些基于纳米颗粒的方案中，乳铁蛋白被纳入递送系统，以运输药物并保护其免受肠道酶降解，从而有利于治疗炎症性肠病和结肠癌的生物利用度。此外，负载乳铁蛋白的纳米颗粒已被制成递送系统，用于运输治疗神经退行性疾病的药物，这些药物无法穿过血脑屏障进入中枢神经系统。本手稿重点关注含有乳铁蛋白作为生物活性成分或用乳铁蛋白作为载体配制的药品，考虑到其与组织中表达的受体的相互作用，这些组织是通过肠胃外或粘膜给药递送的药物的靶点。我们希望本手稿能为制药用乳铁蛋白制剂的治疗可能性提供见解，采用可持续的方法，有助于降低抗菌药物的耐药性，并提高一线药物对肠道慢性炎症和神经退行性疾病的生物利用度。
