a Department of Animal Biology, School of Life Sciences , University of Hyderabad , Hyderabad , India.
b Department of Biotechnology and Bioinformatics, School of Life Sciences , University of Hyderabad , Hyderabad , India.
Syst Biol Reprod Med. 2019 Jun;65(3):205-213. doi: 10.1080/19396368.2018.1519047. Epub 2018 Sep 27.
Multiple prevention therapy has gained importance for the prevention and treatment of sexually transmitted diseases, especially HIV/AIDS. Antiretroviral drugs encapsulated in nanoparticles have been developed for efficient delivery of the drugs to the vaginal surface. Lactoferrin nanoparticles (LFNPs) encapsulating anticancer or antiretroviral drugs are found to be promising agents to specifically deliver drugs at the target sites. Recent studies indicate that the bioavailability is higher for antiretroviral drugs delivered by LFNPs than when the drugs are administered alone. Although LFNP-mediated drug delivery via the oral or vaginal route for the treatment of HIV/AIDS is promising, the effect of such administrations is not well studied. Drug-loaded LFNPs when administered to rats by the vaginal route did not show any effect on the reproductive performance, fertility, and postnatal development. Oral administration of drug-loaded LFNPs caused a significant decrease in litter size, whereas the reproductive performance and postnatal development remained normal. In our model system, the results indicate that vaginal administration of drug-loaded LFNPs appears safer and can be projected for the delivery of antiretroviral agents via the vaginal route. LFNPs: lactoferrin nanoparticles; STIs: sexually transmitted diseases infections; NPs: nanoparticles; LF: lactoferrin; DL-LFNPs: drug loaded lactoferrin nanoparticles; MPT: multiple prevention techniques.
多种预防疗法在性传播疾病（尤其是 HIV/AIDS）的预防和治疗中变得越来越重要。为了将药物高效递送至阴道表面，人们开发了包封于纳米颗粒中的抗逆转录病毒药物。已发现包载抗癌或抗逆转录病毒药物的乳铁蛋白纳米颗粒（LFNPs）是在靶部位特异性递送药物的有前途的药物。最近的研究表明，LFNPs 递送来的抗逆转录病毒药物的生物利用度高于单独给药时的生物利用度。尽管 LFNP 介导的经口或阴道途径递送来治疗 HIV/AIDS 具有广阔的前景，但此类给药的效果尚未得到很好的研究。经阴道途径给予载药 LFNPs 的大鼠未显示对生殖性能、生育力和产后发育有任何影响。经口给予载药 LFNPs 导致胎仔数显著减少，而生殖性能和产后发育仍保持正常。在我们的模型系统中，结果表明阴道给予载药 LFNPs 似乎更安全，并可预测通过阴道途径递送来抗逆转录病毒药物。LFNPs：乳铁蛋白纳米颗粒；STIs：性传播疾病感染；NPs：纳米颗粒；LF：乳铁蛋白；DL-LFNPs：载药乳铁蛋白纳米颗粒；MPT：多种预防技术。
