Huang Xiaobao, Li Fengxian, Wang Fang
Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China.
Pharmaceuticals (Basel). 2023 Feb 6;16(2):246. doi: 10.3390/ph16020246.
As the largest barrier organ of the body, the skin is highly innervated by peripheral sensory neurons. The major function of these sensory neurons is to transmit sensations of temperature, pain, and itch to elicit protective responses. Inflammatory skin diseases are triggered by the aberrant activation of immune responses. Recently, increasing evidence has shown that the skin peripheral nervous system also acts as a regulator of immune responses, particularly innate immunity, in various skin inflammatory processes. Meanwhile, immune cells in the skin can express receptors that respond to neuropeptides/neurotransmitters, leading to crosstalk between the immune system and nervous system. Herein, we highlight recent advances of such bidirectional neuroimmune interactions in certain inflammatory skin conditions.
作为人体最大的屏障器官，皮肤由外周感觉神经元高度支配。这些感觉神经元的主要功能是传递温度、疼痛和瘙痒的感觉以引发保护反应。炎症性皮肤病是由免疫反应的异常激活引发的。最近，越来越多的证据表明，皮肤外周神经系统在各种皮肤炎症过程中也充当免疫反应的调节因子，尤其是先天免疫。同时，皮肤中的免疫细胞可以表达对神经肽/神经递质作出反应的受体，从而导致免疫系统与神经系统之间的相互作用。在此，我们重点介绍在某些炎症性皮肤病中这种双向神经免疫相互作用的最新进展。
