Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA.
Trends Immunol. 2020 Feb;41(2):100-112. doi: 10.1016/j.it.2019.12.004. Epub 2020 Jan 14.
Skin is the largest barrier organ and an important interface between the body and the outside environment. Immune surveillance and homeostatic regulation of skin function are governed by complex interactions between resident lymphoid and myeloid cells and their communications with the surrounding parenchyma. Recent studies have provided exciting insights about the unique characteristics of skin-resident innate lymphoid cells (ILCs). Here, we discuss advances demonstrating how skin ILCs contribute to tissue homeostasis by regulating microbiome balance in steady-state and how their dysregulation can trigger and promote inflammatory skin diseases such as atopic dermatitis and psoriasis. We review the phenotypic and functional similarities and differences of ILCs between the skin and other organs and highlight future areas of investigation for this field.
皮肤是最大的屏障器官，也是身体与外界环境的重要接口。皮肤的免疫监视和功能的动态平衡由常驻淋巴样细胞和髓样细胞之间的复杂相互作用以及它们与周围实质的通讯来调控。最近的研究为皮肤固有淋巴样细胞（ILC）的独特特征提供了令人兴奋的见解。在这里，我们讨论了一些进展，这些进展表明皮肤 ILC 如何通过调节稳态下的微生物组平衡来促进组织稳态，以及它们的失调如何引发和促进特应性皮炎和银屑病等炎症性皮肤病。我们回顾了皮肤和其他器官中 ILC 的表型和功能相似性和差异性，并强调了该领域未来的研究方向。
