RTI Health Solutions, Research Triangle Park, NC, USA.
School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
J Dermatolog Treat. 2023 Dec;34(1):2215356. doi: 10.1080/09546634.2023.2215356.
New treatments for atopic dermatitis (AD) are emerging; however, little is known about the treatment preferences of patients with mild-to-moderate AD. To measure patients' preferences, a cross-sectional, web-based discrete choice experiment (DCE) survey was developed and administered to 300 adults in the United States with a self-reported physician diagnosis of mild-to-moderate AD. In the DCE, respondents evaluated pairs of hypothetical AD treatment profiles defined by efficacy, risk, and mode and frequency of administration attributes. The DCE data were analyzed using a random parameters logit model. Subgroup analysis was used to investigate preference heterogeneity. The results revealed achieving clear or almost clear skin within 3-4 months of treatment was the most important attribute relative to all other study attributes. The results indicated that a topical cream applied twice daily was preferred to systemic treatments. Subgroup analysis revealed that respondents with lower self-assessed disease burden were more likely to choose topical over systemic treatments and less averse to the risk of pain, burning, and/or stinging from the medicine (all other treatment features remaining equal) than respondents with higher self-assessed disease burden. The results of this study can help inform shared decision-making to manage mild-to-moderate AD.
新的特应性皮炎（AD）治疗方法正在出现；然而，对于轻度至中度 AD 患者的治疗偏好知之甚少。为了衡量患者的偏好，开发了一项横断面、基于网络的离散选择实验（DCE）调查，并在美国 300 名自我报告有轻度至中度 AD 医生诊断的成年人中进行了调查。在 DCE 中，受访者评估了通过疗效、风险和管理方式和频率属性定义的两对假设 AD 治疗方案。使用随机参数对数模型分析 DCE 数据。进行了亚组分析以调查偏好异质性。结果表明，与所有其他研究属性相比，在治疗后 3-4 个月内达到皮肤清晰或几乎清晰是最重要的属性。结果表明，每天两次涂抹乳膏优于全身治疗。亚组分析表明，与自我评估疾病负担较高的受访者相比，自我评估疾病负担较低的受访者更倾向于选择局部治疗而不是全身治疗，并且对药物引起的疼痛、灼热和/或刺痛的风险（在所有其他治疗特征保持不变的情况下）的厌恶程度较低。这项研究的结果可以帮助为管理轻度至中度 AD 提供共同决策信息。
