Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Eur Rev Med Pharmacol Sci. 2023 May;27(10):4510-4519. doi: 10.26355/eurrev_202305_32457.
In the last 20 years, the field of myeloproliferative neoplasm (MPN) has changed dramatically. This study aims to provide new ideas for the scientific research of MPN by systematically combing the literature.
CiteSpace and VOSviewer were used to carry out a bibliometric analysis of MPN papers to visualize the development process, research hotspots, and cutting-edge trends in clinical practice, mechanisms, and management strategies related to MPN.
1,099 authors from 736 institutions in 113 countries/regions published 11,922 papers in 1,807 academic journals. The United States and Italy were in the leading positions in this research field. Mayo Clinic is the institution with the largest number of publications. Only a few countries and institutions have shown active cooperation. Ayalew Tefferi and Ruben A. Mesa are outstanding contributors to the field. Blood and Leukemia are considered influential journals based on publications and citations. In this field, the research of MPN mainly focuses on the occurrence and progress mechanism of MPN, the clinical significance of non-driving gene mutation, optimization of primary and secondary thromboprophylaxis, clinical research of long-acting interferon and JAK2 inhibitors, and exploration of better therapies for myelofibrosis (primary and secondary) and post-MPN acute myeloid leukemia (AML).
The research is in a stage of rapid development. The collaboration between different institutions or countries (regions) still has room to grow. The hotspot analysis shows that the research of MPN mainly focuses on gene mutation, thrombosis, new drug applications, disease progression, etc.
在过去的 20 年中，骨髓增殖性肿瘤（MPN）领域发生了巨大变化。本研究旨在通过系统梳理文献，为 MPN 的科学研究提供新的思路。
使用 CiteSpace 和 VOSviewer 对 MPN 文献进行了计量分析，以可视化与 MPN 相关的临床实践、机制和管理策略的发展过程、研究热点和前沿趋势。
来自 736 个机构的 1099 位作者在 1807 种学术期刊上发表了 11922 篇论文。美国和意大利在该研究领域处于领先地位。Mayo Clinic 是发表论文数量最多的机构。只有少数几个国家和机构表现出了积极的合作。Ayalew Tefferi 和 Ruben A. Mesa 是该领域的杰出贡献者。Blood 和 Leukemia 被认为是根据出版物和引文具有影响力的期刊。在这个领域，MPN 的研究主要集中在 MPN 的发生和进展机制、非驱动基因突变的临床意义、初级和次级血栓预防的优化、长效干扰素和 JAK2 抑制剂的临床研究，以及探索更好的治疗方法骨髓纤维化（原发性和继发性）和骨髓增生异常后急性髓系白血病（AML）。
研究处于快速发展阶段。不同机构或国家（地区）之间的合作仍有增长空间。热点分析表明，MPN 的研究主要集中在基因突变、血栓形成、新药应用、疾病进展等方面。
