Rush University Medical Center, Chicago, IL, USA.
Diabetes Research Institute (DRI) and Clinical Cell Transplant Program, University of Miami Miller School of Medicine, Miami, FL, USA
Eur Rev Med Pharmacol Sci. 2023 May;27(10):4678-4687. doi: 10.26355/eurrev_202305_32479.
Inflammatory bowel disease (IBD) is defined as a relapsing and remitting condition characterized by chronic inflammation at different sites in the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) represents the two major forms of IBD. Even though IBD pathophysiology is still not fully understood, genetic factors, environmental factors, dysregulation of both innate and adaptive immune responses, alterations in gut microbiota composition, excessive consumption of saturated fats and cumulative antibiotic exposure have all been suggested to play a role in the development of this condition. Amongst the environmental factors, vitamin D deficiency has been suggested to participate in IBD pathophysiology. Indeed, vitamin D exerts several pleiotropic effects beyond its well-established regulation of bone and calcium homeostasis, including anti-infective, anti-inflammatory and immunomodulatory effects as well as maintenance of gastrointestinal barrier integrity and beneficial gut microbiota composition. In this narrative review, we discuss the role of vitamin D deficiency in IBD pathophysiology as well as the potential therapeutic use of vitamin D for the management of IBD.
炎症性肠病 (IBD) 被定义为一种反复发作和缓解的疾病，其特征是胃肠道的不同部位存在慢性炎症。克罗恩病 (CD) 和溃疡性结肠炎 (UC) 代表了 IBD 的两种主要形式。尽管 IBD 的发病机制尚未完全阐明，但遗传因素、环境因素、先天和适应性免疫反应的失调、肠道微生物群落组成的改变、饱和脂肪的过度消耗以及累积的抗生素暴露都被认为在这种疾病的发展中起作用。在环境因素中，维生素 D 缺乏被认为参与了 IBD 的发病机制。事实上，维生素 D 除了其对骨骼和钙稳态的公认调节作用外，还具有多种多效性作用，包括抗感染、抗炎和免疫调节作用，以及维持胃肠道屏障完整性和有益的肠道微生物群落组成。在这篇叙述性综述中，我们讨论了维生素 D 缺乏在 IBD 发病机制中的作用，以及维生素 D 治疗 IBD 的潜在用途。
