肥胖女性去脂体重与代谢综合征的关系。

Relationship between fat-free mass and metabolic syndrome in obese females.

机构信息

Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valladolid, Investigation Centre on Endocrinology and Nutrition (IEN), University of Valladolid, Valladolid, Spain.

出版信息

Eur Rev Med Pharmacol Sci. 2023 May;27(10):4648-4655. doi: 10.26355/eurrev_202305_32476.

DOI:10.26355/eurrev_202305_32476

PMID:37259765

Abstract

OBJECTIVE

A greater fat-free mass (FFM) could be negatively or positively associated with metabolic syndrome (MS). The objective of this work was to evaluate the relationship of FFM with MS, through three determinations; absolute FFM, relative to body weight FFM% and relative to squared height (FFMi).

PATIENTS AND METHODS

We conducted a cross-sectional study on 1,008 obese Caucasian females. Fat-free mass index (FFMi) was calculated by dividing FFM by squared height [FFM (kg)/height (m2)]. Fat-free mass percentage (FFM%) was calculated (absolute FFM/body weight) x100.

RESULTS

The odds ratio adjusted by age of having MS per tertiles were significantly higher in tertile 3 of FFM (OR=1.74, 95% CI=1.26-2.41; p=0.01) and FFMi (OR=3.38, 95% CI=2.42-3.72; p=0.001) and tertile 2 of FFM (OR=1.45, 95% CI=1.08-1.94; p=0.02) and FFMi (OR=2.37, 95% CI=1.75-3.20; p=0.01) compared with its reference (tertile-1). In contrast, odds ratio adjusted by age of having MS per tertiles were significantly lower in tertile-3 of FFM% (OR=0.29, 95% CI=0.20-0.41; p=0.01) and tertile- 2 of FFM% (OR=0.68, 95% CI=0.51-0.91; p=0.01) compared with its reference (tertile-1).

CONCLUSIONS

The prevalence of MS relative to FFM varies depending on the method used to represent it.

摘要

目的

去脂体重（FFM）的增加可能与代谢综合征（MS）呈负相关或正相关。本研究旨在通过三种方法评估 FFM 与 MS 的关系：绝对 FFM、FFM 占体重的百分比（FFM%）和 FFM 占身高的平方（FFMi）。

患者和方法

我们对 1008 名肥胖白种女性进行了横断面研究。FFM 指数（FFMi）通过将 FFM 除以身高的平方[FFM（kg）/身高（m2）]计算得出。FFM%（绝对 FFM/体重）×100 计算得出。

结果

按年龄调整的 MS 发生优势比在 FFM 三分位的第三分位显著更高（OR=1.74，95%CI=1.26-2.41；p=0.01）和 FFMi（OR=3.38，95%CI=2.42-3.72；p=0.001），在 FFM 三分位的第二分位（OR=1.45，95%CI=1.08-1.94；p=0.02）和 FFMi（OR=2.37，95%CI=1.75-3.20；p=0.01）也显著高于其参考值（三分位-1）。相比之下，按年龄调整的 MS 发生优势比在 FFM%三分位的第三分位（OR=0.29，95%CI=0.20-0.41；p=0.01）和 FFM%三分位的第二分位（OR=0.68，95%CI=0.51-0.91；p=0.01）显著低于其参考值（三分位-1）。