来自 HNNU0524 的瑞马烷型倍半萜类化合物及其抗炎活性评价。
Drimane-type sesquiterpenoids and their anti-inflammatory evaluation from HNNU0524.
机构信息
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, China.
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, China.
出版信息
Nat Prod Res. 2024 May;38(10):1711-1718. doi: 10.1080/14786419.2023.2218008. Epub 2023 Jun 1.
Chemical investigation of a culture broth from the marine-derived fungus HNNU0524 yielded two new compounds including a drimane-type sesquiterpenoid named pyrrnoxin A () and a benzoic acid derivative, pyrrnoxin B (), together with three related known analogues (-). The chemical structures of and were determined by detailed analysis of spectroscopic data, single-crystal X-ray crystallography, quantum mechanics-based DP4+ and ECD calculations. Compounds and moderately inhibited NO production of lipopolysaccharide-induced microglia cells BV2 with IC values of 26.6 and 60.5 µM, respectively.
海洋来源真菌 HNNU0524 的发酵液化学成分研究得到了两个新化合物，包括一个倍半萜类化合物 pyrrnoxin A () 和一个苯甲酸衍生物 pyrrnoxin B ()，以及三个相关的已知类似物 (-)。化合物和的化学结构通过详细的光谱数据分析、单晶 X 射线晶体学、基于量子力学的 DP4+ 和 ECD 计算确定。化合物和对脂多糖诱导的小胶质细胞 BV2 的一氧化氮生成具有中等抑制作用，IC 值分别为 26.6 和 60.5 μM。
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