海洋真菌萜类化合物的结构多样性与生物活性（2020 - 2024年）

Structural Diversity and Bioactivities of Marine Fungal Terpenoids (2020-2024).

作者信息

Jiang Minghua, Chen Senhua, Zhang Zhibin, Xiao Yiwen, Zhu Du, Liu Lan

机构信息

Key Laboratory of Natural Microbial Medicine Research of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang 330013, China.

School of Marine Sciences, Sun Yat-Sen University, Zhuhai 519082, China.

出版信息

Mar Drugs. 2025 Jul 27;23(8):300. doi: 10.3390/md23080300.

DOI:10.3390/md23080300

PMID:40863617

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12387476/

Abstract

Marine-derived fungi have proven to be a rich source of structurally diverse terpenoids with significant pharmacological potential. This systematic review of 119 studies (2020-2024) identifies 512 novel terpenoids, accounting for 87% of the total discoveries to 2020, from five major classes (monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, and triterpenes) isolated from 104 fungal strains across 33 genera. Sesquiterpenoids and diterpenoids constitute the predominant chemical classes, with , , , and being the most productive genera. These fungi were primarily sourced from distinct marine niches, including deep sea sediments, algal associations, mangrove ecosystems, and invertebrate symbioses. Notably, 57% of the 266 tested compounds exhibited diverse biological activities, encompassing anti-inflammatory, antibacterial, antimicroalgal, antifungal, cytotoxic effects, etc. The chemical diversity and biological activities of these marine fungal terpenoids underscore their value as promising lead compounds for pharmaceutical development.

摘要

海洋来源的真菌已被证明是结构多样的萜类化合物的丰富来源，具有显著的药理潜力。这项对119项研究（2020 - 2024年）的系统综述从33个属的104株真菌中分离出512种新型萜类化合物，占截至2020年总发现数的87%，这些萜类化合物来自五个主要类别（单萜、倍半萜、二萜、链状四萜和三萜）。倍半萜类和二萜类是主要的化学类别，其中[此处可能有具体属名缺失]是最具生产力的属。这些真菌主要来自不同的海洋生态位，包括深海沉积物、藻类共生体、红树林生态系统和无脊椎动物共生体。值得注意的是，在266种测试化合物中，57%表现出多种生物活性, 包括抗炎、抗菌、抗微藻、抗真菌、细胞毒性等作用。这些海洋真菌萜类化合物的化学多样性和生物活性突出了它们作为药物开发中有前景的先导化合物的价值。