Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China, Jinan University, Guangzhou 510632, China.
College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
J Asian Nat Prod Res. 2024 Feb;26(2):214-227. doi: 10.1080/10286020.2024.2314188. Epub 2024 Feb 14.
Five new sesquiterpenoids, including a campherenane-type (), a bergamotane-type (), a drimane-type (), and two bisabolane-type () sesquiterpenoids have been isolated from sp. 71-10-1-1. Their structures were determined by spectroscopic analyses, quantum chemical ECD calculations,C chemical shifts calculations, and X-ray crystallography. This is the first report of campherenane-type and drimane-type sesquiterpenoids from . Furthermore, the anti-inflammatory assays of all compounds are evaluated, and the results showed that compounds and exhibited the effects against the production of the pro-inflammatory cytokine TNF-.
从 71-10-1-1 中分离得到了 5 种新的倍半萜，包括 1 种坎菲兰烷型倍半萜（）、1 种佛手烷型倍半萜（）、1 种桃金娘烷型倍半萜（）和 2 种倍半帖烷型（）倍半萜。通过光谱分析、量子化学 ECD 计算、C 化学位移计算和 X 射线晶体学确定了它们的结构。这是首次从 中分离出坎菲兰烷型和桃金娘烷型倍半萜。此外，还对所有化合物的抗炎活性进行了评价，结果表明化合物 和 对促炎细胞因子 TNF-的产生具有抑制作用。
