Quantitative Health Sciences, Mayo Clinic College of Medicine and Science, Jacksonville, Florida.
Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Cancer Prev Res (Phila). 2023 Jun 1;16(6):309-312. doi: 10.1158/1940-6207.CAPR-23-0138.
Reproductive events beginning with pregnancy and ending with remodeling of the breast after cessation of breastfeeding alter breast structure and function and produce dramatic changes in systemic biology. In aggregate, these processes lower overall risk for breast, tubo-ovarian and endometrial cancers, albeit differentially by molecular subtypes of these tumors. Herein, we explore opportunities for research on protective mechanisms operative during this period of the life course, with the goal of encouraging studies to advance cancer prevention. See related article by Getz et al., p. 353.
生殖事件始于怀孕，止于哺乳期结束后乳房的重塑，这些事件改变了乳房的结构和功能，并使全身生物学发生巨大变化。总的来说，这些过程降低了乳腺癌、输卵管卵巢癌和子宫内膜癌的总体风险，尽管这些肿瘤的分子亚型存在差异。在此，我们探讨了在生命历程的这一时期发挥作用的保护机制的研究机会，目的是鼓励开展研究以促进癌症预防。见 Getz 等人的相关文章，第 353 页。
