Ma Xiao, Zhao Long-Gang, Sun Jiang-Wei, Yang Yang, Zheng Jia-Li, Gao Jing, Xiang Yong-Bing
State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Eur J Cancer Prev. 2018 Mar;27(2):144-151. doi: 10.1097/CEJ.0000000000000186.
Epidemiological studies have yielded inconsistent findings on the relationship between breastfeeding and the risk of endometrial cancer. Pertinent studies were identified by searching PubMed, Embase, and Web of Knowledge through February 2015 and by reviewing the reference lists of retrieved articles. Study-specific estimates were pooled using a random-effects model. Dose-response analysis was carried out for every 6-month increase in the duration of breastfeeding in relation to the risk of endometrial cancer. Three prospective and 11 case-control studies were included in this meta-analysis. The pooled estimates for ever compared with never breastfeeding and the longest duration of breastfeeding compared with the shortest were 0.91 [95% confidence interval (CI): 0.75-1.09] and 0.76 (95% CI: 0.59-0.98). The risk of endometrial cancer decreased by 7% for every 6-month increase in the duration of breastfeeding (relative risk: 0.93; 95% CI: 0.88-0.97). This study provides evidence that ever breastfeeding, particularly a longer duration of breastfeeding, is associated with a lower risk of endometrial cancer.
关于母乳喂养与子宫内膜癌风险之间的关系，流行病学研究得出的结果并不一致。通过检索截至2015年2月的PubMed、Embase和Web of Knowledge，并查阅检索到文章的参考文献列表，确定了相关研究。使用随机效应模型汇总特定研究的估计值。针对母乳喂养持续时间每增加6个月与子宫内膜癌风险的关系进行剂量反应分析。该荟萃分析纳入了3项前瞻性研究和11项病例对照研究。曾经母乳喂养与从未母乳喂养相比以及母乳喂养最长持续时间与最短持续时间相比的汇总估计值分别为0.91[95%置信区间（CI）：0.75 - 1.09]和0.76（95%CI：0.59 - 0.98）。母乳喂养持续时间每增加6个月，子宫内膜癌风险降低7%（相对风险：0.93；95%CI：0.88 - 0.97）。本研究提供了证据表明，曾经母乳喂养，尤其是较长时间的母乳喂养，与较低的子宫内膜癌风险相关。
