New horizons in emotional well-being and brain aging: Potential lessons from cross-species research.

Emotional wellbeing (EWB) is a multi-faceted concept of immediate relevance to human health. NIH recently initiated a series of research networks to advance understanding of EWB. Our network (NEW Brain Aging) focuses on mechanistic understanding of EWB in relation to brain aging. Here, by synthesizing the literature on emotional processing and the underlying brain circuit mechanisms in human and non-human animals, we propose a reactivity and reappraisal model for understanding EWB and its age-related changes. This model emphasizes the dynamic interactions between affective stimuli, behavioral/physiological responses, brain emotional states, and subjective feelings. It also aims to integrate the unique emotional processes involved in explaining EWB in aging humans with the emerging mechanistic insight of topologically conserved emotional brain networks from cross-species studies. We also highlight the research opportunities and challenges in EWB and brain aging research and the potential application of the model in addressing these issues.