Paris Brain Institute (ICM), INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France.
INSEAD, Fontainebleau, France.
Nat Rev Neurosci. 2021 May;22(5):309-322. doi: 10.1038/s41583-021-00446-8. Epub 2021 Mar 31.
Increasing evidence suggests that mental health and physical health are linked by neural systems that jointly regulate somatic physiology and high-level cognition. Key systems include the ventromedial prefrontal cortex and the related default-mode network. These systems help to construct models of the 'self-in-context', compressing information across time and sensory modalities into conceptions of the underlying causes of experience. Self-in-context models endow events with personal meaning and allow predictive control over behaviour and peripheral physiology, including autonomic, neuroendocrine and immune function. They guide learning from experience and the formation of narratives about the self and one's world. Disorders of mental and physical health, especially those with high co-occurrence and convergent alterations in the functionality of the ventromedial prefrontal cortex and the default-mode network, could benefit from interventions focused on understanding and shaping mindsets and beliefs about the self, illness and treatment.
越来越多的证据表明，心理健康和身体健康通过共同调节躯体生理学和高级认知的神经系统联系在一起。关键系统包括腹内侧前额叶皮层和相关的默认模式网络。这些系统有助于构建“情境中的自我”模型，将跨时间和感觉模式的信息压缩为体验的潜在原因的概念。情境中的自我模型赋予事件个人意义，并允许对行为和外周生理学进行预测性控制，包括自主神经、神经内分泌和免疫功能。它们指导从经验中学习以及形成关于自我和自己世界的叙述。心理健康和身体健康的障碍，特别是那些伴有腹内侧前额叶皮层和默认模式网络功能高度共存和趋同改变的障碍，可以从专注于理解和塑造关于自我、疾病和治疗的心态和信念的干预中受益。
