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Pericytes Contribute to Flow-induced Pulmonary Hypertension.

作者信息

Klouda Timothy, Tsikis Savas T, Kim Hyunbum, Liu Tiffany, Visner Gary, Fernandez-Gonzalez Angeles, Kourembanas Stella, Puder Mark, Raby Benjamin, Yuan Ke

机构信息

Division of Pulmonary Medicine Boston Children's Hospital Harvard Medical School Boston, Massachusetts.

The Vascular Biology Program and Department of Surgery Boston Children's Hospital Boston, Massachusetts.

出版信息

Am J Respir Cell Mol Biol. 2023 Jun;68(6):705-708. doi: 10.1165/rcmb.2022-0427LE.

DOI:10.1165/rcmb.2022-0427LE
PMID:37260177
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10257066/
Abstract
摘要

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Am J Respir Cell Mol Biol. 2023 Jun;68(6):705-708. doi: 10.1165/rcmb.2022-0427LE.
2
Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension.内皮细胞衍生的成纤维细胞生长因子-2 和白细胞介素-6 介导的周细胞覆盖增加是肺动脉高压中平滑肌样细胞的来源。
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Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension.谱系追踪揭示周细胞在肺动脉高压血管重构中的动态贡献。
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Smooth muscle Cxcl12 activation is associated with vascular remodeling in flow-induced pulmonary hypertension.平滑肌Cxcl12激活与血流诱导的肺动脉高压中的血管重塑相关。
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Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension.新兴的表观遗传学靶点及其对肺动脉高压血管重构的分子影响。
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Direct thrombin inhibitors fail to reverse the negative effects of heparin on lung growth and function after murine left pneumonectomy.直接凝血酶抑制剂无法逆转肝素对小鼠左肺切除术后肺生长和功能的负面影响。
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A pneumonectomy model to study flow-induced pulmonary hypertension and compensatory lung growth.一种用于研究血流诱导性肺动脉高压和代偿性肺生长的肺切除术模型。
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本文引用的文献

1
Mural Cell SDF1 Signaling Is Associated with the Pathogenesis of Pulmonary Arterial Hypertension.壁细胞 SDF1 信号与肺动脉高压的发病机制有关。
Am J Respir Cell Mol Biol. 2020 Jun;62(6):747-759. doi: 10.1165/rcmb.2019-0401OC.
2
Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration.血小板衍生的基质细胞衍生因子-1使肺毛细血管血管龛致敏，以驱动肺泡再生。
Nat Cell Biol. 2015 Feb;17(2):123-136. doi: 10.1038/ncb3096. Epub 2015 Jan 26.
3
Pulmonary arterial hypertension associated with congenital heart disease.先天性心脏病相关肺动脉高压。
Eur Respir Rev. 2012 Dec 1;21(126):328-37. doi: 10.1183/09059180.00004712.
4
Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.肺动脉高压的动物模型：病因发现与药物治疗的希望
Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1013-32. doi: 10.1152/ajplung.00217.2009. Epub 2009 Sep 11.
5
Impaired apoptosis of pulmonary endothelial cells is associated with intimal proliferation and irreversibility of pulmonary hypertension in congenital heart disease.先天性心脏病中肺血管内皮细胞凋亡受损与内膜增生及肺动脉高压的不可逆性有关。
J Am Coll Cardiol. 2007 Feb 20;49(7):803-10. doi: 10.1016/j.jacc.2006.09.049. Epub 2007 Feb 5.