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LINC00426是一种潜在的免疫表型相关生物标志物，也是PAM50腔面B型乳腺癌的总生存预测指标。

LINC00426 is a potential immune phenotype-related biomarker and an overall survival predictor in PAM50 luminal B breast cancer.

作者信息

Fonseca-Montaño Marco Antonio, Cisneros-Villanueva Mireya, Coales Isabelle, Hidalgo-Miranda Alfredo

机构信息

Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.

Programa de Doctorado, Posgrado en Ciencias Biológicas, Unidad de Posgrado, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.

出版信息

Front Genet. 2023 May 16;14:1034569. doi: 10.3389/fgene.2023.1034569. eCollection 2023.

DOI:10.3389/fgene.2023.1034569
PMID:37260772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10228735/
Abstract

Breast cancer (BRCA) represents the most frequent diagnosed malignancy in women worldwide. Despite treatment advances, BRCAs eventually develop resistance to targeted therapies, resulting in poor prognosis. The identification of new biomarkers, like immune-related long non-coding RNAs (lncRNAs), could contribute to the clinical management of BRCA patients. In this report, we evaluated the LINC00426 expression in PAM50 BRCA subtypes from two clinical independent cohorts (BRCA-TCGA and GEO-GSE96058 datasets). Using Cox regression models and Kaplan-Meier survival analyses, we identified that LINC00426 expression was a consistent overall survival (OS) predictor in luminal B (LB) BRCA patients. Subsequently, differential gene expression and gene set enrichment analyses identified that LINC00426 expression was associated with different immune-related and cancer-related pathways and processes in LB BRCA. Additionally, the LINC00426 expression was correlated with the infiltration level of diverse immune cell populations, alongside immune checkpoint and cytolytic activity-related gene expression. This evidence suggests that LINC00426 is a potential biomarker of immune phenotype and an OS predictor in PAM50 LB BRCA.

摘要

乳腺癌（BRCA）是全球女性中最常被诊断出的恶性肿瘤。尽管治疗取得了进展，但BRCA最终会对靶向治疗产生耐药性，导致预后不良。鉴定新的生物标志物，如免疫相关长链非编码RNA（lncRNA），可能有助于BRCA患者的临床管理。在本报告中，我们评估了来自两个临床独立队列（BRCA-TCGA和GEO-GSE96058数据集）的PAM50 BRCA亚型中LINC00426的表达。使用Cox回归模型和Kaplan-Meier生存分析，我们确定LINC00426表达是管腔B（LB）型BRCA患者一致的总生存（OS）预测指标。随后，差异基因表达和基因集富集分析确定LINC00426表达与LB型BRCA中不同的免疫相关和癌症相关途径及过程有关。此外，LINC00426表达与多种免疫细胞群体的浸润水平、免疫检查点和细胞溶解活性相关基因表达相关。这一证据表明，LINC00426是PAM50 LB型BRCA中免疫表型的潜在生物标志物和OS预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/185d578359de/fgene-14-1034569-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/f291dd6f9b29/fgene-14-1034569-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/abea40b1bb03/fgene-14-1034569-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/8e52ae5c8aa3/fgene-14-1034569-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/597c0aa3412b/fgene-14-1034569-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/185d578359de/fgene-14-1034569-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/f291dd6f9b29/fgene-14-1034569-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/abea40b1bb03/fgene-14-1034569-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/8e52ae5c8aa3/fgene-14-1034569-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/597c0aa3412b/fgene-14-1034569-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cc5/10228735/185d578359de/fgene-14-1034569-g005.jpg

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本文引用的文献

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KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications.KRAS 作为炎症肿瘤微环境的调节剂：治疗意义。
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