Qin Shunyi, Peng Yukai, She Fuze, Zhang Jianbin, Li Liuan, Chen Fu
Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Department of Agricultural Science and Technology, Hotan Vocational and Technical College, Hotan, People's Republic of China.
Front Vet Sci. 2023 May 16;10:1184969. doi: 10.3389/fvets.2023.1184969. eCollection 2023.
This paper assessed the positive effects of selenized-oligochitosan (SOC) on zearalenone(ZEN)-induced intestinal dysfunction in piglets. Sixty piglets were randomly divided into 4 groups. Group C was fed the basal diet as a control and Group Z was supplemented with 2 μg/g ZEN in the basal diet; Group ZS1 and ZS2 were supplemented with 0.3 or 0.5 μg/g SOC (calculated by selenium), in addition to 2 μg/g ZEN in the basal diet. After 42 days, ileal mucosal structure, digestive enzyme activities, tight junction protein mRNA expressions, plasma D-lactate and D-xylose contents, and plasma diamine oxidase activities were determined. Compare with Group C, ileal villus height, value of villus height/crypt depth, trypsin, lipase and α-amylase activities, occluding, claudin-1 and ZO-1 mRNA expressions, and plasma D-xylose levels were significantly decreased ( < 0.01) in piglets of group Z; while compare to Group C, ileal crypt depth, plasma D-lactate contents and diamine oxidase activities were significantly increased in piglets of group Z ( < 0.01 or < 0.05). Compare with Group Z, ileal villus height, lipase and α-amylase activities, occluding, claudin-1 and ZO-1 mRNA expressions, and plasma D-xylose levels were significantly elevated in piglets of group ZS1 and ZS2 ( < 0.01); while compare to Group Z, plasma D-lactate and diamine oxidase contents were significantly reduced in piglets of group ZS1 and ZS2 ( < 0.01 or < 0.05). Compare with Group Z, value of villus height/crypt depth and trypsin activity were significantly promoted in piglets of group ZS2 ( < 0.01); whereas ileal crypt depth was significantly reduced in piglets of group ZS2 ( <0.01).Thus, SOC can mitigate ZEN-induced intestinal dysfunction in piglets.
本文评估了硒化低聚壳聚糖（SOC）对玉米赤霉烯酮（ZEN）诱导的仔猪肠道功能障碍的积极影响。60头仔猪随机分为4组。C组饲喂基础日粮作为对照，Z组在基础日粮中添加2μg/g ZEN；ZS1组和ZS2组在基础日粮中除添加2μg/g ZEN外，还分别添加0.3或0.5μg/g SOC（以硒计算）。42天后，测定回肠黏膜结构、消化酶活性、紧密连接蛋白mRNA表达、血浆D-乳酸和D-木糖含量以及血浆二胺氧化酶活性。与C组相比，Z组仔猪回肠绒毛高度、绒毛高度/隐窝深度比值、胰蛋白酶、脂肪酶和α-淀粉酶活性、闭合蛋白、紧密连接蛋白1和闭锁小带蛋白1 mRNA表达以及血浆D-木糖水平显著降低（P<0.01）；而与C组相比，Z组仔猪回肠隐窝深度、血浆D-乳酸含量和二胺氧化酶活性显著升高（P<0.01或P<0.05）。与Z组相比，ZS1组和ZS2组仔猪回肠绒毛高度、脂肪酶和α-淀粉酶活性、闭合蛋白、紧密连接蛋白1和闭锁小带蛋白1 mRNA表达以及血浆D-木糖水平显著升高（P<0.01）；而与Z组相比，ZS1组和ZS2组仔猪血浆D-乳酸和二胺氧化酶含量显著降低（P<0.01或P<0.05）。与Z组相比，ZS2组仔猪绒毛高度/隐窝深度比值和胰蛋白酶活性显著升高（P<0.01）；而ZS2组仔猪回肠隐窝深度显著降低（P<0.01）。因此，SOC可减轻ZEN诱导的仔猪肠道功能障碍。
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