Karmali Dipan, Sowho Mudiaga, Bose Sonali, Pearce Jackson, Tejwani Vickram, Diamant Zuzana, Yarlagadda Keerthi, Ponce Erick, Eikelis Nina, Otvos Tamas, Khan Akram, Lester Michael, Fouras Andreas, Kirkness Jason, Siddharthan Trishul
Division of Pulmonary and Critical Care, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, FL, United States.
Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Front Med (Lausanne). 2023 May 16;10:1160292. doi: 10.3389/fmed.2023.1160292. eCollection 2023.
Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function and may be characteristic of early pulmonary disease. While standard indices like spirometry, body plethysmography, and blood gases have been utilized to assess lung function, they do not provide adequate information on regional ventilatory distribution nor function assessments of ventilation during the respiratory cycle. Emerging technologies such as xenon CT, volumetric CT, functional MRI and X-ray velocimetry can assess regional ventilation using non-invasive radiographic methods that may complement current methods of assessing lung function. As a supplement to current modalities of pulmonary function assessment, functional lung imaging has the potential to identify respiratory disease phenotypes with distinct natural histories. Moreover, these novel technologies may offer an optimal strategy to evaluate the effectiveness of novel therapies and therapies targeting localized small airways disease in preclinical and clinical research. In this review, we aim to discuss the features of functional lung imaging, as well as its potential application and limitations to adoption in research.
肺通气的动态异质性是肺功能的一项重要指标，可能是早期肺部疾病的特征。虽然肺活量测定、体容积描记法和血气分析等标准指标已被用于评估肺功能，但它们无法提供关于区域通气分布的充分信息，也无法对呼吸周期中的通气功能进行评估。氙CT、容积CT、功能磁共振成像和X射线测速仪等新兴技术可以使用非侵入性放射学方法评估区域通气，这可能会补充当前评估肺功能的方法。作为当前肺功能评估方式的补充，功能性肺成像有潜力识别具有不同自然病史的呼吸道疾病表型。此外，这些新技术可能为评估新疗法以及在临床前和临床研究中针对局限性小气道疾病的疗法的有效性提供最佳策略。在本综述中，我们旨在讨论功能性肺成像的特点及其在研究中的潜在应用和局限性。
