Department of Analytical Chemistry, National Institute of Chemistry, Hajdrihova 19, Ljubljana SI-1000, Slovenia.
Anal Chem. 2023 Jul 4;95(26):9863-9871. doi: 10.1021/acs.analchem.3c00774. Epub 2023 Jun 1.
This study aims to investigate the potential benefits of adapting the ablating grid in two-dimensional (2D) and three-dimensional (3D) laser ablation inductively coupled plasma mass spectrometry in a single pulse mapping mode. The goals include enhancing the accuracy of surface sampling of element distributions, improving the control of depth-related sampling, smoothing the post-ablation surface for layer-by-layer sampling, and increasing the image quality. To emulate the capabilities of currently unavailable laser ablation stages, a computational approach using geometrical modeling was employed to compound square or round experimentally obtained 3D crater profiles on variable orthogonal or hexagonal ablation grids. These grids were optimized by minimizing surface roughness as a function of average ablation depth, followed by simulating the post-ablation surface and related image quality. An online application (https://laicpms-apps.ki.si/webapps/home/) is available for users to virtually experiment with contracting/expanding orthogonal and hexagonal ablation grids for generic 3D super-Gaussian laser crater profiles, allowing for exploration of the resulting post-ablation surface layer roughness and depth.
本研究旨在探讨在单次脉冲测绘模式下，将二维（2D）和三维（3D）激光烧蚀电感耦合等离子体质谱中的烧蚀网格进行适配的潜在益处。目标包括提高元素分布表面采样的准确性、改善深度相关采样的控制、使烧蚀后表面平滑以实现逐层采样，以及提高图像质量。为了模拟目前无法获得的激光烧蚀台的功能，我们采用了一种基于几何建模的计算方法，将方形或圆形的实验获得的 3D 弹坑轮廓复合到可变的正交或六方烧蚀网格上。这些网格通过最小化表面粗糙度作为平均烧蚀深度的函数进行了优化，然后模拟了烧蚀后的表面和相关的图像质量。一个在线应用程序（https://laicpms-apps.ki.si/webapps/home/）可供用户虚拟实验使用，以收缩/扩展通用 3D 超高斯激光弹坑轮廓的正交和六方烧蚀网格，探索烧蚀后表面层的粗糙度和深度。
