College of Chemical and Biological Engineering, Zhejiang University, Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, Hangzhou, 310027, China.
Institute of Zhejiang University-Quzhou, Zhejiang Provincial Innovation Center of Advanced Chemicals Technology, Quzhou, 324000, China.
Macromol Biosci. 2023 Oct;23(10):e2300099. doi: 10.1002/mabi.202300099. Epub 2023 Jul 4.
During the COVID-19 (Corona Virus Disease 2019) pandemic, traditional medical goggles are not only easy to attach bacteria and viruses in long-term exposure, but easy to fogged up, which increases the risk of infection and affects productivity. Bacterial adhesion and fog can be significantly inhibited through the hydrogel coatings, owing to super hydrophilic properties. On the one hand, hydrogel coatings are easy to absorb water and swell in wet environment, resulting in reduced mechanical properties, even peeling off. On the other hand, the hydrogel coatings don't have intrinsic antibacterial properties, which still poses a potential risk of bacterial transmission. Herein, an anti-swelling and antibacterial hydrogel coating is synthesized by 2-hydroxyethyl methacrylate (HEMA), acrylamide (AM), dimethylaminoethyl acrylate bromoethane (IL-Br), and poly(sodium-p-styrenesulfonate) (PSS). Due to the self-driven entropy reduction effect of polycation and polyanion, an ion cross-linking network is formed, which endows the hydrogel coating with excellent antiswelling performance. Moreover, because of the synergistic effect of highly hydrated surfaces and the active bactericidal effect from quaternary ammonium cations, the hydrogel coating exhibits outstanding antifouling performances. This work develops a facile strategy to fabricate anti-swelling, antifouling, and antifogging hydrogel coatings for the protection of medical goggles, and also for biomedical and marine antifouling fields.
在 COVID-19（新型冠状病毒病 2019）大流行期间，传统的医用护目镜不仅在长期暴露下容易附着细菌和病毒，而且容易起雾，这增加了感染的风险并影响了生产力。水凝胶涂层由于具有超亲水性，可显著抑制细菌黏附和起雾。一方面，水凝胶涂层在潮湿环境中很容易吸收水分并膨胀，导致机械性能降低，甚至剥落。另一方面，水凝胶涂层本身没有内在的抗菌性能，仍然存在细菌传播的潜在风险。在此，通过 2-羟乙基甲基丙烯酸酯 (HEMA)、丙烯酰胺 (AM)、二甲氨基乙基丙烯酰胺溴乙烷 (IL-Br) 和聚（苯乙烯磺酸钠）(PSS) 合成了一种抗溶胀和抗菌水凝胶涂层。由于聚阳离子和聚阴离子的自驱动熵减少效应，形成了离子交联网络，使水凝胶涂层具有优异的抗溶胀性能。此外，由于高水合表面的协同作用和季铵阳离子的活性杀菌作用，水凝胶涂层表现出出色的防污性能。这项工作开发了一种简便的策略来制备抗溶胀、防污和防雾水凝胶涂层，用于保护医用护目镜，以及用于生物医学和海洋防污领域。
