Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China.
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China.
Biochim Biophys Acta Gene Regul Mech. 2024 Mar;1867(1):194952. doi: 10.1016/j.bbagrm.2023.194952. Epub 2023 May 30.
Ubiquitination is a fascinating post-translational modification that has received continuous attention since its discovery. In this review, we first provide a concise overview of the E3 ubiquitin ligases, delving into classification, characteristics and mechanisms of ubiquitination. We then specifically examine the ubiquitination pathways mediated by the N/C-degrons, discussing their unique features and substrate recognition mechanisms. Finally, we offer insights into the current state of development pertaining to inhibitors that target the N/C-degron pathways, as well as the promising advances in the field of PROTAC (PROteolysis TArgeting Chimeras). Overall, this review offers a comprehensive understanding of the rapidly-evolving field of ubiquitin biology.
泛素化是一种令人着迷的翻译后修饰，自发现以来一直受到持续关注。在这篇综述中，我们首先简要概述了 E3 泛素连接酶，深入探讨了其分类、特征和泛素化机制。然后，我们专门研究了 N/C-降解结构域介导的泛素化途径，讨论了它们独特的特征和底物识别机制。最后，我们深入探讨了针对 N/C-降解结构域途径的抑制剂的发展现状，以及 PROTAC（蛋白水解靶向嵌合体）领域的有前途的进展。总的来说，这篇综述全面介绍了泛素生物学这一快速发展的领域。
