Molecular Oncology Programme, Growth Factors, Nutrients and Cancer Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, ES-28029, Spain.
Molecular Oncology Programme, Growth Factors, Nutrients and Cancer Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, ES-28029, Spain.
Trends Mol Med. 2023 Jul;29(7):489-511. doi: 10.1016/j.molmed.2023.04.004. Epub 2023 May 30.
In recent years dietary interventions have become a promising tool in cancer treatment and have demonstrated a powerful ability to alter metabolism and tumor growth, development, and therapeutic response. However, because the mechanisms underlying dietary therapeutics are poorly understood, they are frequently ignored as a potential line of treatment for cancer. We discuss the proposed mechanisms behind the anticancer effects of various diets and their development for clinical use. This review aims to provide researchers and clinicians in the field of oncology with a complete overview of the contemporary landscape of nutritional interventions and precision nutrition as cancer therapeutics, and offers a perspective on the steps necessary to establish nutritional interventions as a standard line of treatment.
近年来，饮食干预已成为癌症治疗中一种有前途的手段，并且已证明其具有强大的改变代谢和肿瘤生长、发展以及治疗反应的能力。然而，由于人们对饮食疗法的机制了解甚少，因此它们常常被忽视为癌症治疗的一种潜在方法。我们讨论了各种饮食抗癌作用的提出的机制及其用于临床应用的发展。本综述旨在为肿瘤学领域的研究人员和临床医生提供营养干预和精准营养作为癌症治疗的当代全景图，并就将营养干预作为标准治疗方法所需的步骤提供一个视角。
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