Electrical and Computer Engineering, Queen's University, Kingston, K7L 3N6, Canada.
Biomedical and Molecular Sciences, Queen's University, Kingston, K7L 3N6, Canada.
Sci Rep. 2023 Jun 1;13(1):8886. doi: 10.1038/s41598-023-36030-6.
An investigation of the deactivation of pathogens using electromagnetic waves in the microwave region of the spectrum is achieved using custom-built waveguide structures. The waveguides feature sub-wavelength gratings to allow the integration of an air cooling system without disturbing the internal propagating fields. The waveguides are tapered to accommodate an experimental sample internally with sufficient surrounding airflow. The proposed methodology allows for precise control over power densities due to the well-defined fundamental mode excited in each waveguide, in addition to temperature control of the sample due to microwave exposure over time. Human coronavirus (HCoV-229E) is investigated over the 0-40 GHz range, where a peak 3-log viral reduction is observed in the 15.0-19.5 GHz sub-band. We conclude HCoV-229E has an intrinsic resonance in this range, where nonthermal structure damage is optimal through the structure-resonant energy transfer effect.
采用定制的波导结构，利用电磁波在微波区域对病原体进行失活研究。这些波导采用亚波长光栅，可在不干扰内部传播场的情况下集成空气冷却系统。波导逐渐变细，以在内部容纳实验样本，同时提供足够的周围气流。由于每个波导中激发的明确定义的基本模式，以及由于微波随时间暴露导致的样品温度控制，所提出的方法允许对功率密度进行精确控制。在 0-40 GHz 的范围内研究人类冠状病毒 (HCoV-229E)，在 15.0-19.5 GHz 的子频段中观察到峰值 3 对数的病毒减少。我们得出结论，HCoV-229E 在该范围内具有固有共振，其中通过结构共振能量转移效应，非热结构损伤是最佳的。
