O'Sullivan Dylan E, Hillier Troy W R, Brenner Darren R, Peters Cheryl E, King Will D
Department of Oncology, University of Calgary, Calgary, AB, Canada.
Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB, Canada.
Cancer Causes Control. 2023 Sep;34(9):791-799. doi: 10.1007/s10552-023-01719-6. Epub 2023 Jun 1.
The objective was to explore the relationship of sun behavior patterns with the risk of developing non-Hodgkin lymphoma (NHL).
Sun behavior information from Alberta's Tomorrow Project, CARTaGENE, and Ontario Health Study were utilized. The relationship between time in the sun during summer months and risk of NHL was assessed using Cox proportional hazard models with age as the time scale and adjustment for confounders. Cohorts were analyzed separately and hazard ratios (HR) pooled with random effects meta-analysis. Joint effects of time in the sun and use of sun protection were examined. Patterns of exposure were explored via combinations of weekday and weekend time in the sun.
During an average follow-up of 7.6 years, 205 NHL cases occurred among study participants (n = 79,803). Compared to < 30 min daily in the sun, we observed HRs of 0.84 (95% CI 0.55-1.28) for 30-59 min, 0.63 (95% CI 0.40-0.98) for 1-2 h, and 0.91 (95% CI 0.61-1.36) for > 2 h. There was suggestive evidence that > 2 h was protective against NHL with use of sun protection, but not without it. Compared to < 30 min daily, moderate exposure (30 min to 2 h on weekdays or weekend) was associated with a lower risk of NHL (HR 0.63, 95% CI 0.43-0.92), while intermittent (< 30 min on weekdays and > 2 h on weekends) and chronic (> 2 h daily) were not.
This study provides evidence of a protective effect of moderate time spent in the sun on NHL risk.
本研究旨在探究晒太阳行为模式与非霍奇金淋巴瘤（NHL）发病风险之间的关系。
利用了来自艾伯塔省明日项目、CARTaGENE和安大略省健康研究的晒太阳行为信息。采用以年龄为时间尺度并对混杂因素进行调整的Cox比例风险模型，评估夏季晒太阳时间与NHL发病风险之间的关系。对各个队列分别进行分析，并采用随机效应荟萃分析汇总风险比（HR）。研究了晒太阳时间与使用防晒措施的联合效应。通过工作日和周末晒太阳时间的组合来探究暴露模式。
在平均7.6年的随访期间，研究参与者（n = 79,803）中出现了205例NHL病例。与每天晒太阳时间少于30分钟相比，我们观察到，晒太阳30 - 59分钟的HR为0.84（95%可信区间0.55 - 1.28），1 - 2小时的HR为0.63（95%可信区间0.40 - 0.98），超过2小时的HR为0.91（95%可信区间0.61 - 1.36）。有提示性证据表明，超过2小时且使用防晒措施可预防NHL，但不使用防晒措施则不然。与每天少于30分钟相比，适度暴露（工作日或周末30分钟至2小时）与较低的NHL发病风险相关（HR 0.63，95%可信区间0.43 - 0.92），而间歇性暴露（工作日少于30分钟且周末超过2小时）和长期暴露（每天超过2小时）则不然。
本研究提供了证据，表明适度晒太阳时间对NHL发病风险具有保护作用。
