Lu Demin, Xu Fei, Hu Kaiming, Yin Li, Duan Huijie, Zhang Jiaojiao, Zhang SuZhan
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Oncotarget. 2017 May 24;8(37):62358-62370. doi: 10.18632/oncotarget.18140. eCollection 2017 Sep 22.
Non-Hodgkin lymphoma is a heterogeneous group of lympho-proliferative disorders. We performed a meta-analysis to summarize the available evidence from case-control studies and cohort study on the inconsistent association between occupational sun exposure and the risk of non-Hodgkin lymphoma. We searched PubMed, ISI web of science, the Cochrane Library, EMBASE and reference lists for relevant articles. Study specific odds ratios or relative risk and 95% confidence intervals were pooled by using fixed-effects or random-effects models. Ten case-control studies and one cohort study were included in the meta-analysis. Overall, the pooled odds ratios for occupational ultraviolet exposure and non-Hodgkin lymphoma risk was 1.15(95% confidence intervals: 0.99, 1.32; = 44.4%). Occupational sun exposure was positively associated with the risk of NHL 1.14 (95% confidence intervals: 1.05, 1.23; =25.4% p for heterogeneity =0.202) in Caucasian population. Common subtypes of non-Hodgkin lymphoma and ultraviolet exposure had the negative results. The pooled odds ratios was 1.16, (95%confidence intervals: 0.90, 1.50) for T-cell non-Hodgkin lymphoma; 0.79, (95%confidence intervals: 0.61, 1.02) for B-cell non-Hodgkin lymphoma; 1.13, (95%confidence intervals: 0.96, 1.34) for chronic lymphocytic leukemia; 1.25, (95%confidence intervals: 0.95, 1.64) for males; 1.49, (95%confidence intervals: 0.99, 2.25) for females. Data suggested that occupational ultraviolet exposure was a risk factor for non-Hodgkin lymphoma in Caucasian population. While, there had no relationship between occupational ultraviolet exposure and risk of non-Hodgkin lymphoma in general population as well as non-Hodgkin lymphoma common subtypes. Besides, gender specific occupational sun exposure also indicated no association on risk of non-Hodgkin lymphoma.
非霍奇金淋巴瘤是一组异质性的淋巴增殖性疾病。我们进行了一项荟萃分析，以总结病例对照研究和队列研究中关于职业性阳光暴露与非霍奇金淋巴瘤风险之间不一致关联的现有证据。我们在PubMed、科学网ISI、考克兰图书馆、EMBASE以及参考文献列表中搜索相关文章。通过固定效应或随机效应模型汇总研究特定的比值比或相对风险以及95%置信区间。荟萃分析纳入了10项病例对照研究和1项队列研究。总体而言，职业性紫外线暴露与非霍奇金淋巴瘤风险的合并比值比为1.15（95%置信区间：0.99，1.32；I² = 44.4%）。在白种人群中，职业性阳光暴露与非霍奇金淋巴瘤风险呈正相关，比值比为1.14（95%置信区间：1.05，1.23；I² = 25.4%，异质性p = 0.202）。非霍奇金淋巴瘤的常见亚型与紫外线暴露的结果为阴性。T细胞非霍奇金淋巴瘤的合并比值比为1.16（95%置信区间：0.90，1.50）；B细胞非霍奇金淋巴瘤为0.79（95%置信区间：0.61，1.02）；慢性淋巴细胞白血病为1.13（95%置信区间：0.96，1.34）；男性为1.25（95%置信区间：0.95，1.64）；女性为1.49（95%置信区间：0.99，2.25）。数据表明，职业性紫外线暴露是白种人群中非霍奇金淋巴瘤的一个风险因素。然而，在一般人群以及非霍奇金淋巴瘤常见亚型中，职业性紫外线暴露与非霍奇金淋巴瘤风险之间没有关系。此外，按性别分类的职业性阳光暴露与非霍奇金淋巴瘤风险也无关联。
