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儿童化脓性链球菌性咽炎合并坏死性肌炎:诊断、治疗及随访。

Streptococcal pharyngitis in a Child, Complicated with a Necrotizing Myositis: Diagnosis, Management and Follow-Up.

机构信息

Division of Gynaecology, University Medical Center Ljubljana, Ljubljana, Slovenia.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

出版信息

Am J Case Rep. 2023 Jun 2;24:e939538. doi: 10.12659/AJCR.939538.

Abstract

BACKGROUND Group A streptococcus is a common cause of pharyngitis and can also cause a wide variety of invasive infections, including necrotizing soft-tissue infections. The presented case is one of the rare occurrences of necrotizing soft-tissue infection as a consequence of hematogenous spread and is the first described pediatric case of streptococcal myositis that was clearly preceded by pharyngitis. CASE REPORT A 2.5-year-old boy, previously healthy, fell ill 3 days before admission with high-grade fever, diffuse erythematous truncal rash and, later, with pain in the left lower leg. The next day, scarlet fever was diagnosed, and he was started on oral penicillin V. In the following 2 days, the fever and pain in the leg did not subside; edema and redness of the left shin appeared. On admission, he was febrile and had tachycardia, and the mouth examination was consistent with bacterial pharyngitis. The left shin was grossly edematous, with diffuse bluish skin discoloration. Empiric antibiotic treatment with benzylpenicillin and clindamycin was started. An ultrasound scan of the left shin revealed extensive myonecrosis. Urgent fasciotomy was done, and necrotic muscles were surgically excised. CONCLUSIONS Streptococcal necrotizing myositis is exceedingly rare. Due to potentially life-threatening complications and a need for urgent surgical intervention, clinicians must have a low threshold of suspicion, even in atypical pathogenesis and presentation.

摘要

背景

A 组链球菌是咽炎的常见病因,也可引起多种侵袭性感染,包括坏死性软组织感染。本病例为罕见的血源性播散导致的坏死性软组织感染之一,也是首例明确由咽炎引发的儿童链球菌肌炎病例。

病例报告

一名 2.5 岁的男孩,既往健康,于入院前 3 天出现高热、弥漫性红斑性躯干皮疹,随后出现左小腿疼痛。次日,诊断为猩红热,给予口服青霉素 V。在接下来的 2 天中,发热和腿部疼痛未缓解;左小腿出现肿胀和红肿。入院时,患儿发热、心动过速,口腔检查符合细菌性咽炎。左小腿明显肿胀,皮肤呈弥漫性蓝色变色。给予青霉素和克林霉素经验性抗生素治疗。左小腿超声检查显示广泛的肌坏死。紧急行筋膜切开术,切除坏死的肌肉。

结论

链球菌坏死性肌炎极为罕见。由于可能危及生命的并发症和需要紧急手术干预,即使在非典型发病机制和表现时,临床医生也必须保持较低的怀疑阈值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8bf/10241107/f3d3ead118f2/amjcaserep-24-e939538-g001.jpg

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