Chopra P, Manga A, Nayak N C
J Natl Cancer Inst. 1979 Apr;62(4):1089-95.
During experiments to study the evolution of hepatocellular carcinoma in adult male Wistar rats by exposing regenerating livers to the action of small doses of dimethylnitrosamine (DMN) or N-2-acetylaminofluorene (AAF), several primary sarcomas of the liver were incidentally observed. The morphology and behavior of the tumors suggest their origin from Kupffer's cells. Kupffer cell sarcomas occurred more frequently when 70% hepatectomy was used as the regenerative stimulus. None of the 36 animals treated with AAF alone and 2 of the 38 rats given DMN only had this tumor.
在通过将再生肝脏暴露于小剂量二甲基亚硝胺（DMN）或N - 2 - 乙酰氨基芴（AAF）的作用来研究成年雄性Wistar大鼠肝细胞癌演变的实验过程中，偶然观察到几例原发性肝脏肉瘤。肿瘤的形态和行为表明它们起源于库普弗细胞。当采用70%肝切除术作为再生刺激时，库普弗细胞肉瘤的发生更为频繁。单独接受AAF治疗的36只动物中无一出现这种肿瘤，仅接受DMN治疗的38只大鼠中有2只出现了这种肿瘤。
