Argus M F, Hoch-Ligeti C, Arcos J C, Conney A H
J Natl Cancer Inst. 1978 Aug;61(2):441-9.
The effect of administration of beta-naphthoflavone (beta-NF) or pregnenolone-16alpha-carbonitrile (PCN) on the hepatocarcinogenicity of dimethylnitrosamine (DMN) in male SD rats was explored. Both beta-NF and PCN are potent repressors of the low Michaelis constant enzymatic form of DMN-demethylase, a mixed-function oxidase that catalyzes DMN demethylation. DMN-induced hepatocarcinogenesis was inhibited by PCN and was enhanced by beta-NF. Seven liver tumors were found in 45 rats fed DMN plus PCN compared to 14 liver tumors in 43 rats fed DMN alone; 32 liver tumors were found in 43 rats fed DMN plus beta-NF. No liver tumors were detected in rats that received only PCN, beta-NF, or the administration vehicles. Of the 53 liver tumors observed, 53% were angiosarcomas; this type of tumor was found in all 3 groups of rats that received DMN.
探讨了给予β-萘黄酮（β-NF）或孕烯醇酮-16α-腈（PCN）对雄性SD大鼠二甲基亚硝胺（DMN）致癌性的影响。β-NF和PCN都是低米氏常数的DMN-脱甲基酶（一种催化DMN去甲基化的混合功能氧化酶）酶形式的有效抑制剂。PCN抑制了DMN诱导的肝癌发生，而β-NF则增强了这种作用。在45只喂食DMN加PCN的大鼠中发现了7个肝肿瘤，相比之下，43只单独喂食DMN的大鼠中有14个肝肿瘤；在43只喂食DMN加β-NF的大鼠中发现了32个肝肿瘤。在仅接受PCN、β-NF或给药载体的大鼠中未检测到肝肿瘤。在所观察到的53个肝肿瘤中，53%为血管肉瘤；这种肿瘤在所有3组接受DMN的大鼠中均有发现。
