Research Center for Clinical Medical Sciences, The Fourth Hospital of Shijiazhuang, Shijiazhuang, China.
J Obstet Gynaecol Res. 2023 Aug;49(8):2056-2062. doi: 10.1111/jog.15705. Epub 2023 Jun 2.
To investigate the associations of serum trace elements (iron, zinc, and copper) between women with different pregnancy outcomes.
About 774 pregnant women who came to The Fourth Hospital of Shijiazhuang for prenatal examination were investigated. The concentrations of trace elements in the serum of pregnant women in the third trimester were collected. Multivariate logistic regression was used to analyze the relationship between serum trace element levels and the different pregnancy outcomes. Multiple linear regression was used to analyze the relationship between serum trace elements levels and hypersensitive-C-reactive-protein.
Results of the multiple logistic regression showed that zinc, copper and copper/zinc ratio were found to be associated with the risk of gestational diabetes mellitus, and zinc was a protective factor (p = 0.002) while copper and copper/zinc ratio as risk factors (p = 0.030 and p = 0.001, respectively) after adjusting for major confounders. It was found that iron and zinc were negatively associated with the risk of moderate or severe anemia (p = 0.022 and p = 0.001, respectively). In contrast, the copper/zinc ratio was positively related to the risk of moderate or severe anemia (p = 0.021). The adjusted relationships between copper and copper/zinc ratio with premature rupture of membranes were statistically significant (p = 0.007 and p = 0.037). Iron and zinc were negatively associated with the risk of chorioamnionitis, while copper and copper/zinc ratio were positively associated with the risk of chorioamnionitis (all p < 0.05).
Serum iron, zinc and copper levels are closely related to pregnancy outcomes.
探讨不同妊娠结局的女性血清微量元素（铁、锌、铜）之间的关系。
对 774 名来石家庄市第四医院进行产前检查的孕妇进行调查。收集孕妇孕晚期血清微量元素浓度。采用多变量 logistic 回归分析血清微量元素水平与不同妊娠结局的关系。采用多元线性回归分析血清微量元素水平与超敏-C 反应蛋白的关系。
多因素 logistic 回归结果显示，锌、铜和铜/锌比值与妊娠期糖尿病的发病风险有关，锌是保护因素（p=0.002），而铜和铜/锌比值是危险因素（p=0.030 和 p=0.001），调整了主要混杂因素后。发现铁和锌与中度或重度贫血的发病风险呈负相关（p=0.022 和 p=0.001）。相反，铜/锌比值与中度或重度贫血的发病风险呈正相关（p=0.021）。铜和铜/锌比值与胎膜早破的调整关系具有统计学意义（p=0.007 和 p=0.037）。铁和锌与绒毛膜羊膜炎的发病风险呈负相关，而铜和铜/锌比值与绒毛膜羊膜炎的发病风险呈正相关（均 p<0.05）。
血清铁、锌和铜水平与妊娠结局密切相关。
