（）叶和果实乙醇提取物作为抗高尿酸血症的潜在药物在小鼠中的作用。

Pak J Biol Sci. 2023 Jan;26(2):63-71. doi: 10.3923/pjbs.2023.63.71.

Background and Objective: Hyperuricemia is a disease triggered by disorders of uric acid metabolism. Therefore, this study evaluated the potential of leaves ethanolic extract of Etlingera hemisphaerica (LE3H) and fruits ethanolic extract E. hemisphaerica (FE3H) to restore hyperuricemia in mice. Materials and Methods: Six groups (A0, A1, A2, A3, A4 and A5) each consisted of four male mice. Hyperuricemia in mice was induced by giving 0.3 mL of fresh chicken liver juice (FCLJ) for seven days (A1, A2, A3, A4 and A5). The condition of hyperuricemia in A1 is not neutralized. Meanwhile, hyperuricemia conditions in A2, A3, A4 and A5 were neutralized for seven days by giving 0.01 mg g1 body weight (BW) allopurinol, 0.13, 0.26 and 0.36 mg g1 BW LE3H. The control group (A0) only received double-distilled water in the same way. Blood uric acid levels were measured with the GCU Meter Device before and after the induction of hyperuricemia and after efforts to neutralize the hyperuricemia condition. Six groups (B0, B1, B2, B3, B4, B5) each consisting of four male mice were also provided to test the potential of FE3H. The recovery potential FE3H against hyperuricemia was tested separately in the same way as was done for LE3H. Results: Giving FCLJ significantly increased (140.00-187.00%) uric acid compared to the control, so hyperuricemia was achieved. Doses of 0.13, 0.26 and 0.36 mg g1 BW LE3H significantly recovered hyperuricemia as much as 54.09, 56.14 and 60.88%, respectively. Meanwhile, doses of 0.13, 0.26 and 0.36 mg g1 FE3H significantly recovered hyperuricemia as much as 60.37, 62.24 and 65.572%, respectively. The LE3H and FE3H at the same dose showed that FE3H had a higher potential to restore hyperuricemia than LE3H. Conclusion: Leave and fruit ethanolic extract of E. hemisphaerica can potentially restore hyperuricemia in mice.

背景和目的：高尿酸血症是由尿酸代谢紊乱引起的疾病。因此，本研究评估了Etlingera hemisphaerica叶和果实乙醇提取物（LE3H 和 FE3H）恢复小鼠高尿酸血症的潜力。材料和方法：六组（A0、A1、A2、A3、A4 和 A5）每组各有四只雄性小鼠。用新鲜鸡肝汁（FCLJ）诱导小鼠高尿酸血症，连续 7 天（A1、A2、A3、A4 和 A5）。A1 组的高尿酸血症状况未得到中和。同时，A2、A3、A4 和 A5 组通过给予 0.01mg g1体重别嘌呤醇、0.13、0.26 和 0.36mg g1BW LE3H 连续 7 天来中和高尿酸血症。对照组（A0）仅以同样的方式接受双蒸水。在诱导高尿酸血症前后以及中和高尿酸血症后，使用 GCU Meter 设备测量血尿酸水平。六组（B0、B1、B2、B3、B4、B5）每组各有四只雄性小鼠，也被用来测试 FE3H 的潜力。FE3H 对高尿酸血症的恢复潜力以与 LE3H 相同的方式分别进行测试。结果：给予 FCLJ 可使尿酸显著升高（140.00-187.00%），与对照组相比，从而实现高尿酸血症。0.13、0.26 和 0.36mg g1BW LE3H 剂量可分别使高尿酸血症恢复 54.09%、56.14%和 60.88%。同时，0.13、0.26 和 0.36mg g1FE3H 剂量可分别使高尿酸血症恢复 60.37%、62.24%和 65.572%。相同剂量的 LE3H 和 FE3H 表明 FE3H 恢复高尿酸血症的潜力高于 LE3H。结论：E. hemisphaerica叶和果实乙醇提取物可潜在恢复小鼠高尿酸血症。