Ioannidou M, Tsotridou E, Samoladas E, Tragiannidis A, Kouskouras K, Sfougaris D, Spyridakis I, Foroulis C, Galli-Tsinopoulou A, Hatzipantelis E
Children's and Adolescent's Hematology-Oncology Unit of 2nd Department of Pediatrics, Aristotle University of Thessaloniki, AHEPA University General Hospital, Thessaloniki, Greece.
2nd Department of Orthopedic Surgery, Aristotle University of Thessaloniki, "Gennimatas" General Hospital, Thessaloniki, Greece.
Balkan J Med Genet. 2023 May 2;25(2):77-81. doi: 10.2478/bjmg-2022-0022. eCollection 2023 May.
Ewing sarcoma (ES), described as a diffuse endothelioma of the bone, is divided into two categories: osseous and extraosseous, which mainly affects adolescents. Extraosseous Ewing Sarcomas (EES) are rare tumors originating from soft tissues. Their clinical presentation depends mainly on the primary location of the tumor and are highly chemosensitive and radiosensitive. The purpose of this study was to describe the clinical characteristics and outcomes of 3 children with EES and uncommon presentation treated in our Unit. The diagnosis of EES was confirmed by biopsy and cytogenetic analysis with fluorescence in situ hybridization (FISH). Surgical excision was planned as primary treatment, followed by adjuvant chemotherapy according to EURO-E.W.I.N.G protocol. To date, all patients are alive, 1, 3 and 4 years after completion of treatment, with no signs of recurrence or metastasis.
尤因肉瘤（ES），被描述为一种骨的弥漫性内皮瘤，分为两类：骨内型和骨外型，主要影响青少年。骨外型尤因肉瘤（EES）是起源于软组织的罕见肿瘤。其临床表现主要取决于肿瘤的原发部位，并且对化疗和放疗高度敏感。本研究的目的是描述在我们科室接受治疗的3例表现不常见的EES患儿的临床特征及治疗结果。EES的诊断通过活检及荧光原位杂交（FISH）细胞遗传学分析得以证实。计划将手术切除作为主要治疗方法，随后根据欧洲E.W.I.N.G方案进行辅助化疗。迄今为止，所有患者在完成治疗后1年、3年和4年仍存活，无复发或转移迹象。
