肠道微生物群在伴有认知功能障碍的糖尿病性周围神经病变大鼠中的作用。
The role of gut microbiota in diabetic peripheral neuropathy rats with cognitive dysfunction.
作者信息
Huang Wei, Lin Ziqiang, Sun Ailing, Deng JieMin, Manyande Anne, Xiang Hongbing, Zhao Gao Feng, Hong Qingxiong
机构信息
Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
School of Human and Social Sciences, University of West London, London, United Kingdom.
出版信息
Front Microbiol. 2023 Apr 18;14:1156591. doi: 10.3389/fmicb.2023.1156591. eCollection 2023.
INTRODUCTION
Owing to advancements in non-invasive magnetic resonance imaging, many studies have repeatedly showed that diabetes affects the central nervous system in the presence of peripheral neuropathy, suggesting a common or interacting pathological mechanism for both complications.
METHODS
We aimed to investigate the role of abnormal gut microbiota in rats with diabetic peripheral neuropathy (DPN) combined with cognitive dysfunction. Glucose-compliant rats with nerve conduction deficits were screened as a successful group of DPN rats. The DPN group was then divided into rats with combined cognitive impairment (CD) and rats with normal cognitive function (NCD) based on the results of the Novel object recognition test. Rat feces were then collected for 16S rRNA gene sequencing of the intestinal flora.
RESULTS AND DISCUSSION
The results revealed that abnormalities in , , , and may induce DPN complicated by cognitive dysfunction.
引言
由于非侵入性磁共振成像技术的进步，许多研究反复表明，糖尿病在存在周围神经病变的情况下会影响中枢神经系统，这表明两种并发症存在共同或相互作用的病理机制。
方法
我们旨在研究异常肠道微生物群在糖尿病周围神经病变（DPN）合并认知功能障碍大鼠中的作用。筛选出具有神经传导缺陷的血糖正常大鼠作为成功的DPN大鼠组。然后根据新物体识别测试的结果，将DPN组分为合并认知障碍（CD）的大鼠和认知功能正常（NCD）的大鼠。然后收集大鼠粪便进行肠道菌群的16S rRNA基因测序。
结果与讨论
结果显示，[此处原文缺失具体菌群名称]的异常可能诱发DPN并发认知功能障碍。
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