Chat generative pre-trained transformer (ChatGPT) is an artificial intelligence chatbot that uses natural language processing that can respond to human input in a conversational manner. ChatGPT has numerous applications in the health care system including dentistry; it is used in diagnoses and for assessing disease risk and scheduling appointments. It also has a role in scientific research. In the dental field, it has provided many benefits such as detecting dental and maxillofacial abnormalities on panoramic radiographs and identifying different dental restorations. Therefore, it helps in decreasing the workload. But even with these benefits, one should take into consideration the risks and limitations of this chatbot. Few articles mentioned the use of ChatGPT in dentistry. This comprehensive review represents data collected from 66 relevant articles using PubMed and Google Scholar as databases. This review aims to discuss all relevant published articles on the use of ChatGPT in dentistry.