Keikhaie Khadije Rezaie, Mohammadi Mohammad Hasan, Saravani Khadijeh, Kahkhaie Leli Rezaie, Mir Fatemeh
Department of Obstetrics and Gynecology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran.
Maedica (Bucur). 2023 Mar;18(1):42-49. doi: 10.26574/maedica.2023.18.1.42.
Epilepsy is a common and devastating neurological disease. Its treatment, especially when using phenobarbital, causes liver complications, and it is therefore essential to identify a way to reduce liver complications. This study aimed to investigate the protective effect of ursodeoxycholic acid on liver function in pediatric patients with seizure treated with phenobarbital. Materials and methods: The present study was conducted on 80 patients (40 in the placebo group and 40 in the ursodeoxycholic acid group). To assess the effect of intervention, liver enzyme levels after five weeks of treatment were recorded. Independent t-test and ANOVA repeated measures were used to compare the means. The study results showed that the administration of ursodeoxycholic acid had a relative effect in improving liver function in patients with liver injury caused by phenobarbital.
癫痫是一种常见且严重的神经系统疾病。其治疗，尤其是使用苯巴比妥时，会引发肝脏并发症，因此确定一种减少肝脏并发症的方法至关重要。本研究旨在探讨熊去氧胆酸对接受苯巴比妥治疗的癫痫患儿肝功能的保护作用。材料与方法：本研究对80例患者进行（安慰剂组40例，熊去氧胆酸组40例）。为评估干预效果，记录治疗五周后的肝酶水平。采用独立t检验和重复测量方差分析来比较均值。研究结果表明，熊去氧胆酸给药对改善苯巴比妥所致肝损伤患者的肝功能有相对作用。
