Bawku Presbyterian Hospital, Bawku, Upper East Region, Ghana; Department of Medical Laboratory Sciences, School of Allied Health, Sciences College of Health and Allied Sciences, University of Cape Coast, Ghana.
School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.
Blood Cells Mol Dis. 2023 Sep;102:102757. doi: 10.1016/j.bcmd.2023.102757. Epub 2023 May 25.
In sub-Saharan Africa, the prevailing high ambient temperatures should warrant increased daily water intake (DWI) to prevent haemo-concentration and its potential to confound patients' laboratory data.
To assess the impact that the recommended DWI has on the haemato-biochemical variables in a tropical setting.
This quasi-experimental study recruited 101 apparently healthy individuals (18-60 years) in the Bawku municipality. DWI, anthropometrics, and haemato-biochemical variables were assessed at baseline. Participants were encouraged to increase their DWI to ≥4 L over a 30-day period; haemato-biochemical variables were re-evaluated. Total body water (TBW) was anthropometrically estimated.
The median post-treatment DWI significantly increased; consequently, anaemia cases increased by >20-fold (2.0 % vs 47.5 % post-treatment). RBC count, platelet count, WBC count, and median haemoglobin significantly decreased compared to baseline (p < 0.0001). Biochemically, median plasma osmolality (p < 0.0001), serum sodium (p < 0.0001), serum potassium (p = 0.0012) and random blood sugar (p = 0.0403) significantly decreased. Compared to baseline, significantly higher proportion of participants classified as thrombocytopenic (8.9 % vs 3.0 %), hyponatraemia (10.9 % vs 2.0 %), or normal osmolarity (77.2 % vs 20.8 %). There were differential bivariate correlations between pre- and post-treatment haemato-biochemical variables.
Sub-optimal DWI is a likely confounder in haemato-biochemical data interpretation in the tropics.
在撒哈拉以南非洲，普遍较高的环境温度应该保证人们每天增加水分摄入（DWI），以防止血液浓缩及其对患者实验室数据产生潜在影响。
评估在热带环境下，推荐的 DWI 对血液生化变量的影响。
本准实验研究在博克瓦市招募了 101 名看似健康的成年人（18-60 岁）。在基线时评估 DWI、人体测量学和血液生化变量。鼓励参与者在 30 天内将 DWI 增加到≥4L；重新评估血液生化变量。使用人体测量法估计总体水（TBW）。
治疗后 DWI 的中位数显著增加；因此，贫血病例增加了 20 多倍（治疗后为 2.0% vs. 47.5%）。与基线相比，RBC 计数、血小板计数、WBC 计数和中位数血红蛋白显著降低（p<0.0001）。在生化方面，血浆渗透压中位数（p<0.0001）、血清钠（p<0.0001）、血清钾（p=0.0012）和随机血糖（p=0.0403）显著降低。与基线相比，血小板减少症（8.9% vs. 3.0%）、低钠血症（10.9% vs. 2.0%）或正常渗透压（77.2% vs. 20.8%）的参与者比例显著增加。治疗前后血液生化变量之间存在差异的双变量相关性。
在热带地区，不适当的 DWI 可能会对血液生化数据的解释产生干扰。
